2,6-Dihydroxypurine

Modify Date: 2024-01-02 21:02:22

2,6-Dihydroxypurine Structure
2,6-Dihydroxypurine structure
Common Name 2,6-Dihydroxypurine
CAS Number 69-89-6 Molecular Weight 152.111
Density 1.6±0.1 g/cm3 Boiling Point 834.9ºC at 760 mmHg
Molecular Formula C5H4N4O2 Melting Point 300 °C
MSDS Chinese USA Flash Point 458.7ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2,6-Dihydroxypurine


Xanthine is a purine base found in most human body tissues and fluids and in other organisms.

 Names

Name 7H-xanthine
Synonym More Synonyms

 2,6-Dihydroxypurine Biological Activity

Description Xanthine is a purine base found in most human body tissues and fluids and in other organisms.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro A number of stimulants are derived from Xanthine including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 834.9ºC at 760 mmHg
Melting Point 300 °C
Molecular Formula C5H4N4O2
Molecular Weight 152.111
Flash Point 458.7ºC
Exact Mass 152.033432
PSA 94.40000
LogP -0.81
Index of Refraction 1.636
Storage condition Store at RT.
Water Solubility NH4OH: freely soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZD7700000
CHEMICAL NAME :
Xanthine
CAS REGISTRY NUMBER :
69-89-6
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C5-H4-N4-O2
MOLECULAR WEIGHT :
152.13
WISWESSER LINE NOTATION :
T56 BM DN FMVMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 mg/kg/18W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
262 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3901 No. of Facilities: 68 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2546 (estimated) No. of Female Employees: 786 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317-H319
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36;R43
Safety Phrases S36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS ZD7700000
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles240

More Articles
Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.

Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014)

Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nige...

Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS.

Molecules 20 , 11490-507, (2015)

The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Dese...

Spironolactone and dimethylsulfoxide effect on glucose metabolism and oxidative stress markers in polycystic ovarian syndrome rat model.

Exp. Clin. Endocrinol. Diabetes 122(3) , 154-62, (2014)

Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose...

 Synonyms

UREOUS ACID
Xan
xanthicoxide
Dioxopurine
9H-xanthine
2,5-DIFLUOROTHIOBENZAMIDE
usafcb-17
Xanthine
9H-Purine-2,6(1H,3H)-dione
Purine-2,6(1H,3H)-dione
Xanthin
ISOXANTHINE
2,6-Dihydroxypurine
MFCD00078453
3,7-dihydropurine-2,6-dione
Xanthione
EINECS 200-718-6
3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 3,7-dihydro-
3,7-dihydro-purine-2,6-dione
2,6(1H,3H)-Purinedione