Uric Acid

Modify Date: 2024-01-02 17:33:04

Uric Acid Structure
Uric Acid structure
 Common Name Uric Acid
CAS Number 69-93-2 Molecular Weight 168.110
Density 1.9±0.1 g/cm3 Boiling Point 863ºC at 760 mmHg
Molecular Formula C5H4N4O3 Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point 475.7ºC

 Use of Uric Acid


Uric acid is an endogenous antioxidant that scavenges reactive oxygen species (ROS) including singlet oxygen, oxygen radicals, and peroxynitrite.

 Names

Name 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Synonym More Synonyms

 Uric Acid Biological Activity

Description Uric acid is an endogenous antioxidant that scavenges reactive oxygen species (ROS) including singlet oxygen, oxygen radicals, and peroxynitrite.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Uric acid is an endogenous antioxidant that scavenges reactive oxygen species (ROS) including singlet oxygen, oxygen radicals, and peroxynitrite. Incubation with indomethacin significantly increases malondialdehyde (MDA) levels in Caco-2 cells compare to those not treated indomethacin. Incubation with both indomethacin and Uric acid significantly decreases MDA levels compare to those grown in the presence of indomethacin alone. Co-treatment of cells with indomethacin and Uric acid significantly decreases ROS levels compare to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both indomethacin and Uric acid is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[1].
In Vivo When mice treated with indomethacin are concurrently administered Uric acid orally, ulcer areas are significantly reduced, in a Uric acid dose-dependent manner. Indomethacin increases the ratio of crypt depth to villous height in the ileum, while the ratio is significantly lower when mice are concurrently administered Uric acid orally. Administration of indomethacin also increases the histopathological score of tissue damage in the small intestine, while mice concurrently administered Uric acid orally has a significantly lower histopathological score. The ileal levels of malondialdehyde (MDA) in indomethacin-induced enteropathy model mice orally administered Uric acid are also significantly lower than the levels in mice administered indomethacin alone[1].
Cell Assay Human colon carcinoma cells (Caco-2) are used and grown in Eagle’s minimum essential medium supplemented with 10% FBS, 1% non-essential amino acid mixture, and 1% Pen-Strep at 37°C in a humidified atmosphere with 5% CO2. Caco-2 cells are incubated with indomethacin in the presence or absence of Uric acid for 24 or 48 hours[1].
Animal Admin To evaluate the effect of oral administration of Uric acid on NSAID-induced enteropathy, mice are given Uric acid (2.5, 10, 25, 100, or 250 mg/kg body weight) suspended in 0.5% carboxymethyl cellulose orally at 30 minutes before, and 12 hours after indomethacin or vehicle treatment. To evaluate the effect of intraperitoneal administration of inosinic acid plus potassium oxonate on NSAID-induced enteropathy, mice are given inosinic acid (500 mg/kg body weight) plus potassium oxonate (250 mg/kg body weight) 24 intraperitoneally at 30 minutes before, and 12 hours after indomethacin or vehicle treatment[1].
References

[1]. Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017 Nov;32(11):1839-1845.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 863ºC at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C5H4N4O3
Molecular Weight 168.110
Flash Point 475.7ºC
Exact Mass 168.028336
PSA 114.37000
LogP -1.08
Index of Refraction 1.721
Storage condition Store at RT.
Stability Stable. Incompatible with acids, bases, oxidising agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU7050080
CHEMICAL NAME :
Uric acid
CAS REGISTRY NUMBER :
69-93-2
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C5-H4-N4-O3
MOLECULAR WEIGHT :
168.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5040 mg/kg
SEX/DURATION :
male 4 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mmol/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 4,87,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82048 No. of Facilities: 246 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 2320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82048 No. of Facilities: 1210 (estimated) No. of Industries: 5 No. of Occupations: 8 No. of Employees: 17397 (estimated) No. of Female Employees: 12409 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R33
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YU7050080
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

2,6,8-trioxypurine
1H-Purine-2,6,8 (3H)-trione, 7,9-dihydro-
1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-
[14C]-Uric acid
2,6,8-trioxopurine
EINECS 200-720-7
7,9-Dihydro-1H-purine-2,6,8(3H)-trione
1H-Purine-2,6,8-triol
urate
[3H]-Uric acid
2,6,8-trihydroxypurine
Uric Acid
Uric acid (8CI)
MFCD00005712
1H-Purine-2,6,8(3H)-trione, 7,9-dihydro- (9CI)
1H-Purine-2,6,8(3H)-trione,7,9-dihydro
Lithic acid
7,9-dihydro-3H-purine-2,6,8-trione
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