6-Maleimidocaproic acid-PFP ester

Modify Date: 2024-01-03 11:45:18

6-Maleimidocaproic acid-PFP ester structure	Common Name	6-Maleimidocaproic acid-PFP ester
	CAS Number	692739-25-6	Molecular Weight	377.26300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₂F₅NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 6-Maleimidocaproic acid-PFP ester

6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	pentafluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
Synonym	More Synonyms

Description	6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

6-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid pentafluorophenyl ester

6-maleimidohexanoic acid pentafluorophenyl ester

pentafluorophenyl 6-maleimidohexanoate

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