5(6)-Carboxyfluorescein

Modify Date: 2026-07-04 17:01:47

5(6)-Carboxyfluorescein Structure
5(6)-Carboxyfluorescein structure
Common Name 5(6)-Carboxyfluorescein
CAS Number 72088-94-9 Molecular Weight 376.32
Density N/A Boiling Point N/A
Molecular Formula C21H12O7 Melting Point 275 °C
MSDS Chinese USA Flash Point N/A

 Use of 5(6)-Carboxyfluorescein


5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; cell-impermeant 5,6-FAM can also be used as a nonfixable polar tracer to investigate fusion, lysis and gap-junctional communication and to detect changes in cell or liposome volume.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 5(6)-Carboxyfluorescein
Synonym More Synonyms

 5(6)-Carboxyfluorescein Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; cell-impermeant 5,6-FAM can also be used as a nonfixable polar tracer to investigate fusion, lysis and gap-junctional communication and to detect changes in cell or liposome volume.
Related Catalog
References

[1]. Babcock DF. Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J Biol Chem. 1983 May 25;258(10):6380-9.

[2]. Bonizzoni M, et al. PAMAM dendrimer-induced aggregation of 5(6)-carboxyfluorescein. J Org Chem. 2012 Feb 3;77(3):1258-66.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Melting Point 275 °C
Molecular Formula C21H12O7
Molecular Weight 376.32
PSA 226.58000
LogP 6.72800
InChIKey BPVHBBXCESDRKW-UHFFFAOYSA-N
SMILES O=C(O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21.O=C(O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21
Storage condition Store at 2-8

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases 37/39-26-36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS CQ7700000
HS Code 29335995

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 29335995

 Articles64

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Characteristics and photo-responsive release property of liposome containing 7-acetoxy coumarin.

J. Nanosci. Nanotechnol. 11 , 10262-10270, (2011)

A photo-responsive liposome was developed by loading 7-acetoxy coumarin (ATC) in egg phosphatidylcholine (EPC) liposome. ATC was derivetized from 7-hydroxy coumarin using sodium acetate. The ATC-loade...

A novel assay for detecting fusion pore formation: implications for the fusion mechanism.

Biochemistry 52(47) , 8510-7, (2013)

Membrane fusion is broadly envisioned as a two- or three-step process proceeding from contacting bilayers through one or two semistable, nonlamellar lipidic intermediate structures to a fusion pore. A...

Development of novel diolein-niosomes for cutaneous delivery of tretinoin: influence of formulation and in vitro assessment.

Int. J. Pharm. 477(1-2) , 176-86, (2014)

This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol(®), as carriers for cutaneous drug delivery. The model drug was ...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 3',6'-dihydroxy-3-oxo-, compd. with 3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid (1:1)
3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid - 3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid (1:1)
MFCD00151081
Fluoresceincarboxylic Acid
EINECS 276-331-1

 5(6)-Carboxyfluorescein | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 5(6)-Carboxyfluorescein?
A: CAS number of 5(6)-Carboxyfluorescein is 72088-94-9.
Q: What is the safety information for 5(6)-Carboxyfluorescein?
A: Safety information for 5(6)-Carboxyfluorescein: 37/39-26-36.
Q: What is the molecular formula of 5(6)-Carboxyfluorescein?
A: Molecular formula of 5(6)-Carboxyfluorescein is C21H12O7.
Q: What is the English name of 5(6)-Carboxyfluorescein?
A: The English name of 5(6)-Carboxyfluorescein is 5(6)-Carboxyfluorescein.
Q: What are the uses of 5(6)-Carboxyfluorescein?
A: Main uses of 5(6)-Carboxyfluorescein: 5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; cell-impermeant 5,6-FAM can also be used as a nonfixable polar tracer to investigate fusion, lysis and gap-junctional communication and to detect changes in cell or liposome volume.
Q: What is the SMILES notation of 5(6)-Carboxyfluorescein?
A: SMILES notation of 5(6)-Carboxyfluorescein is O=C(O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21.O=C(O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21.
Q: What English synonyms does 5(6)-Carboxyfluorescein have?
A: English synonyms of 5(6)-Carboxyfluorescein: Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 3',6'-dihydroxy-3-oxo-, compd. with 3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid (1:1), 3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid - 3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid (1:1), MFCD00151081, Fluoresceincarboxylic Acid, EINECS 276-331-1.
Q: What is the molecular weight of 5(6)-Carboxyfluorescein?
A: Molecular weight of 5(6)-Carboxyfluorescein is 376.32.
Q: What are the storage conditions for 5(6)-Carboxyfluorescein?
A: Storage conditions for 5(6)-Carboxyfluorescein: Store at 2-8.
Q: What is the LogP of 5(6)-Carboxyfluorescein?
A: LogP of 5(6)-Carboxyfluorescein is 6.72800.

 5(6)-Carboxyfluoresceinfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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