(D-Pro2,D-Trp7·9)-Substance P acetate salt

Modify Date: 2025-08-26 17:53:24

(D-Pro2,D-Trp7·9)-Substance P acetate salt structure	Common Name	(D-Pro2,D-Trp7·9)-Substance P acetate salt
	CAS Number	80434-86-2	Molecular Weight	1515.82000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇₄H₁₀₆N₂₀O₁₃S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of (D-Pro2,D-Trp7·9)-Substance P acetate salt

[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].

Name	[d-pro2, d-trp7,9]-substance p
Synonym	More Synonyms

Description	[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	[D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 µM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action than Aprepitant (HY-10052) on cancer or normal cell lines[3].
In Vivo	[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1]. [D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2]. Animal Model: Adult pigmented rabbits (1.5-3 kg)[1] Dosage: 0.03, 0.3, 3, and 30 nmol Administration: Intravitreal injection or topical application onto the eye, 60 μL Result: Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
References	[1]. Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. [2]. Håkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. [3]. Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English.

Molecular Formula	C₇₄H₁₀₆N₂₀O₁₃S
Molecular Weight	1515.82000
Exact Mass	1514.80000
PSA	573.51000
LogP	6.76800

2-Pro-7,9-Trp-substance p

2-Pro-7,9-Trp-sp

Pttsp

Pt-sp

<D-Pro2,D-Trp7,9>-SP

dt79

[DPro2,DTrp7,9] Substance P

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China
Product Name: [D-PRO2, D-TRP7,9]-SUBSTANCE P
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Purity: 98.0%
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Use of (D-Pro2,D-Trp7·9)-Substance P acetate salt

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