MB-07811

Modify Date: 2024-01-08 16:34:15

MB-07811 structure	Common Name	MB-07811
	CAS Number	852948-13-1	Molecular Weight	514.98
	Density	1.27±0.1 g/cm3(Predicted)	Boiling Point	660.6±55.0 °C(Predicted)
	Molecular Formula	C₂₈H₃₂ClO₅P	Melting Point	77-82 °C
	MSDS	N/A	Flash Point	N/A

Use of MB-07811

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].

Name	4-[[4-[[(2R,4S)-4-(3-chlorophenyl)-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-propan-2-ylphenol

Description	MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Metabolic Disease
Target	Thyroid hormone receptor-β[2]
In Vitro	MB-07811 is potential for liver targeting with a low affinity for thyroid hormone receptors (TRβ Ki = 14.6 ± 0.5 μM; TRα Ki = 12.5 ± 0.6 μM)[2].
In Vivo	MB-07811 (0.3-30 mg/kg; orally once daily for 14 days) reduces cholesterol and triglycerides in diet-induced obese mice[2]. Animal Model: 4-week-old male C57BL/6 mice (diet-induced obese (DIO) mice)[2] Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Orally once daily; 14 days Result: Reduced total plasma cholesterol, and reduced plasma triglycerides (40%) at the highest doses.
References	[1]. Cable EE, et al. Reduction of hepatic steatosis in rats and mice after treatment with aliver-targeted thyroidhormone receptor agonist. Hepatology. 2009 Feb;49(2):407-17. [2]. Erion MD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5.

Density	1.27±0.1 g/cm3(Predicted)
Boiling Point	660.6±55.0 °C(Predicted)
Melting Point	77-82 °C
Molecular Formula	C₂₈H₃₂ClO₅P
Molecular Weight	514.98
Exact Mass	514.16800
PSA	74.80000
LogP	8.08420
Storage condition	2-8°C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MB-07811 (VK-2809)
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: MB-07811 (VK-2809)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: MB-07811 (VK-2809)
Price: $1500.0/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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