ALK5-IN-16i
Modify Date: 2024-10-05 00:07:34
ALK5-IN-16i structure
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Common Name | ALK5-IN-16i | ||
|---|---|---|---|---|
| CAS Number | 864375-44-0 | Molecular Weight | 427.541 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H21N5O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ALK5-IN-16iA potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA. |
| Name | ALK5-IN-16i |
|---|
| Description | A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA. |
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| References | References 1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38. View Related Products by Target TGF beta Receptor (TGFBR) |
| Molecular Formula | C20H21N5O2S2 |
|---|---|
| Molecular Weight | 427.541 |