Azido-PEG4-Amine

Modify Date: 2024-01-05 08:16:12

Azido-PEG4-Amine Structure
Azido-PEG4-Amine structure
Common Name Azido-PEG4-Amine
CAS Number 951671-92-4 Molecular Weight 262.30600
Density 1.10 g/mL Boiling Point N/A
Molecular Formula C10H22N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azido-PEG4-Amine


PROTAC Linker 20 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 20 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanamine
Synonym More Synonyms

 Azido-PEG4-Amine Biological Activity

Description PROTAC Linker 20 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 20 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.10 g/mL
Molecular Formula C10H22N4O4
Molecular Weight 262.30600
Exact Mass 262.16400
PSA 112.69000
LogP 0.47486
Appearance of Characters liquid
Index of Refraction 1.4670 to 1.4710
Storage condition 2-8°C

 Safety Information

RIDADR UN 2735 8/PG III
Packaging Group III
Hazard Class 8

 Synonyms

O-(2-Aminoethyl)-O'-(2-azidoethyl)triethylene Glycol
14-Azido-3,6,9,12-tetraoxatetradecan-1-amine
Azido-PEG4-Amine
O-(2-Aminoethyl)-O’-(2-azidoethyl)triethylene Glycol
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