SCD1-IN-1

Modify Date: 2024-01-02 17:59:21

SCD1-IN-1 Structure
SCD1-IN-1 structure
Common Name SCD1-IN-1
CAS Number 1111078-63-7 Molecular Weight 395.37
Density N/A Boiling Point N/A
Molecular Formula C20H20F3NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SCD1-IN-1


SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1].

 Names

Name SCD1-IN-1

 SCD1-IN-1 Biological Activity

Description SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1].
Related Catalog
Target

SCD1[1].

In Vitro SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM[1].
In Vivo SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model[1]. Animal Model: Hamster ear model[1] Dosage: 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL. Administration: Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks. Result: Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.
References

[1]. Li Jin, et al. Phenoxy-pyrrolidine derivative and its use and compositions Patent. WO2009019566.

 Chemical & Physical Properties

Molecular Formula C20H20F3NO4
Molecular Weight 395.37