BML-278

Modify Date: 2024-01-02 11:57:17

BML-278 structure	Common Name	BML-278
	CAS Number	15301-69-6	Molecular Weight	391.460
	Density	1.2±0.1 g/cm3	Boiling Point	564.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₅NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	294.9±30.1 °C

Use of BML-278

Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].

Name	flavoxate
Synonym	More Synonyms

Description	Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. Arcaniolo D, et al. Flavoxate: present and future. Eur Rev Med Pharmacol Sci. 2015;19(5):719-31. [2]. Sugaya K, et al. Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. J Urol. 2014 Oct;192(4):1278-85.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

References

[1]. Arcaniolo D, et al. Flavoxate: present and future. Eur Rev Med Pharmacol Sci. 2015;19(5):719-31.

[2]. Sugaya K, et al. Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. J Urol. 2014 Oct;192(4):1278-85.

Density	1.2±0.1 g/cm3
Boiling Point	564.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₅NO₄
Molecular Weight	391.460
Flash Point	294.9±30.1 °C
Exact Mass	391.178345
PSA	59.75000
LogP	5.18
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.591

N/A

CAS#:91830-40-9

~96%

BML-278

CAS#:15301-69-6

Literature: Yamamoto Chemical Industrial Co., Ltd.; Osaka Municipal Government Patent: US4634768 A1, 1987 ;

Benzoic acid, 2...

CAS#:91099-99-9

Benzoyl chloride

CAS#:98-88-4

~92%

BML-278

CAS#:15301-69-6

Literature: Yamamoto Chemical Industrial Company, Limited; Osaka Municipal Government Patent: US4533732 A1, 1985 ;

N/A

CAS#:91849-12-6

~80%

BML-278

CAS#:15301-69-6

Literature: Yamamoto Chemical Industrial Co., Ltd.; Osaka Municipal Government Patent: US4634768 A1, 1987 ;

Precursor 2
CAS#:91099-99-9 Benzoic acid, 2... CAS#:98-88-4 Benzoyl chloride
DownStream 0

flavoxate

3-Methylflavone-8-carboxylic Acid b-Piperidinoethyl Ester

Genurin

Flavossato [DCIT]

Flavoxatum [INN-Latin]

3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic Acid 2-(1-Piperidinyl)ethyl Ester

Flavoxato [INN-Spanish]

MFCD00210291

Flavossato

Flavoxate [INN:BAN]

Flavoxatum

REC 7-0040

2-(Piperidin-1-yl)ethyl-3-methyl-4-oxo-2-phenyl-4H-chromen-8-carboxylat

2-(Piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate

2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

Urispas

2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

2-Piperidinoethyl 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate

EINECS 239-337-5

Bladderon

Spasuret

2-Piperidinoethyl 3-Methylflavone-8-carboxylate

Flavoxato

4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester

BML-278

Use of BML-278

Names

BML-278 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms