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替泊沙林

替泊沙林用途

替泊沙林是COX和5-脂氧合酶(5-LO)的双重抑制剂,具有强大的抗炎活性和良好的胃肠道状况[1]。

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替泊沙林名称

[ CAS 号 ]:
103475-41-8

[ 中文名 ]:
替泊沙林

[ 英文名 ]:
Tepoxalin

[英文别名 ]:

Zubrin
Tepoxalinum [Latin]
Tepoxalin
Tepoxalin [USAN:INN]
Tepoxaline
Tepoxalina [Spanish]
Tepoxalina
Tepoxaline [French]

替泊沙林生物活性

[ 描述 ]:

替泊沙林是COX和5-脂氧合酶(5-LO)的双重抑制剂,具有强大的抗炎活性和良好的胃肠道状况[1]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. Argentieri DC, et al. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther. 1994 Dec;271(3):1399-408.

替泊沙林物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
573.0±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₀ClN₃O₃

[ 分子量 ]:
385.844

[ 闪点 ]:
300.3±32.9 °C

[ 精确质量 ]:
385.119324

[ PSA ]:
67.59000

[ LogP ]:
3.84

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.610

替泊沙林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8002500

CHEMICAL NAME :: 1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-me thyl-

CAS REGISTRY NUMBER :: 103475-41-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H20-Cl-N3-O3

MOLECULAR WEIGHT :: 385.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1085 mg/kg/31D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7280 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 54600 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

替泊沙林

替泊沙林用途

替泊沙林名称

替泊沙林生物活性

替泊沙林物理化学性质

替泊沙林毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

替泊沙林合成路线

详细合成路线

替泊沙林上下游产品

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