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尿刊酸

尿刊酸用途

Urocanic acid 是皮肤中的主要光线受体,天然以反式尿刊酸存在。

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尿刊酸名称

[ CAS 号 ]:
104-98-3

[ 中文名 ]:
尿刊酸

[ 英文名 ]:
Urocanic acid

[中文别名 ]:

[英文别名 ]:

(2E)-3-(1H-Imidazol-4-yl)acrylic acid
urocanoic acid
(2E)-3-(1H-imidazol-4-yl)prop-2-enoic acid
(E)-3-(1H-imidazol-4-yl)acrylic acid
RARECHEM AL BK 0762
(Z/E)-3-(1H-imidazol-4-yl)-2-propenoic acid
3-(1H-imidazol-4-yl)prop-2-enoic acid
imidazoleacrylicacid
(E)-3-(1H-imidazol-4-yl)-2-propenoic acid
3-imidazol-4-ylacrylic

尿刊酸生物活性

[ 描述 ]:

Urocanic acid 是皮肤中的主要光线受体,天然以反式尿刊酸存在。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

在表皮的上层形成尿刊酸(UCA),其中富含组氨酸的丝状蛋白,在胱天蛋白酶-14裂解聚丝蛋白后产生,被蛋白酶分解成组分氨基酸[1]。

[参考文献]

[1]. Gibbs NK, et al. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem Photobiol Sci. 2008 Jun;7(6):655-67.

[相关活性小分子]

尿刊酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
456.9±20.0 °C at 760 mmHg

[ 熔点 ]:
226-228 °C(lit.)

[ 分子式 ]:
C₆H₆N₂O₂

[ 分子量 ]:
138.124

[ 闪点 ]:
230.1±21.8 °C

[ 精确质量 ]:
138.042923

[ PSA ]:
65.98000

[ LogP ]:
0.01

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.674

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
SLIGHTLY SOLUBLE

尿刊酸MSDS

尿刊酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3425200

CHEMICAL NAME :: Imidazole-4-acrylic acid

CAS REGISTRY NUMBER :: 104-98-3

BEILSTEIN REFERENCE NO. :: 0081405

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H6-N2-O2

MOLECULAR WEIGHT :: 138.14

WISWESSER LINE NOTATION :: T5M CNJ D1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

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尿刊酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NI3425200

[ 海关编码 ]:
29332990

尿刊酸合成路线

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尿刊酸下游产品

尿刊酸海关

[ 海关编码 ]: 29332990

尿刊酸文献

Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.

Pharm. Res. 32 , 2625-35, (2015)

An unknown UV 280 nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence i...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.

Eur. J. Med. Chem. 46 , 1483-98, (2011)

A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been s...

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尿刊酸