尼泊金乙酯
尼泊金乙酯用途
尼泊金乙酯名称
[ CAS 号 ]:
120-47-8
[ 中文名 ]:
尼泊金乙酯
[ 英文名 ]:
Ethylparaben
[中文别名 ]:
[英文别名 ]:
- Sobrol A
- Easeptol
- 4-Hydroxybenzoic acid, ethyl ester
- Ethyl parasept
- Benzoic acid, 4-hydroxy-, ethyl ester
- ethyl p-hydroxybenzoate
- para-hydroxybenzoic acid ethyl ester
- nipazina
- Ethyl chemosept
- 4-hydroxybenzoic ethyl ester
尼泊金乙酯生物活性
尼泊金乙酯物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
297.5±0.0 °C at 760 mmHg
[ 熔点 ]:
114-117 °C(lit.)
[ 分子式 ]:
C9H10O3
[ 分子量 ]:
166.174
[ 闪点 ]:
120.3±12.6 °C
[ 精确质量 ]:
166.062988
[ PSA ]:
46.53000
[ LogP ]:
2.40
[ 外观性状 ]:
白色结晶粉末
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.539
[ 储存条件 ]:
库房低温,通风,干燥
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
[ 水溶解性 ]:
水溶性:不溶;水溶解度:885 mg/l 25 °C;易溶于:醇,乙醚;微溶:氯仿
尼泊金乙酯MSDS
尼泊金乙酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DH2190000
- CHEMICAL NAME :
- Benzoic acid, p-hydroxy-, ethyl ester
- CAS REGISTRY NUMBER :
- 120-47-8
- BEILSTEIN REFERENCE NO. :
- 1101972
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C9-H10-O3
- MOLECULAR WEIGHT :
- 166.19
- WISWESSER LINE NOTATION :
- QR DVO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 520 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 504 gm/kg/12W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 45600 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 440 mg/L
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82869 No. of Facilities: 103 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3241 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82869 No. of Facilities: 307 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 4591 (estimated) No. of Female Employees: 1145 (estimated)
尼泊金乙酯安全信息
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi: Irritant;
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36-S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
1
[ RTECS号 ]:
DH2190000
[ 海关编码 ]:
2918290000
尼泊金乙酯合成路线
尼泊金乙酯上下游产品
尼泊金乙酯上游产品
尼泊金乙酯下游产品
尼泊金乙酯制备
1.由对羟基苯甲酸与乙醇酯化,经精制即可。
2.主要采用酯化法。 由苯酚钾在加压下与二氧化碳反应先制成对羟基苯甲酸,然后将对羟基苯甲酸与乙醇在硫酸催化剂存在下进行酯化反应,最后经洗涤、脱色、重结晶、离心脱水、干燥而得。
尼泊金乙酯海关
[ 海关编码 ]: 2918290000
[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
尼泊金乙酯文献
Talanta 143 , 254-62, (2015)
Parabens are widely used in dairy products, such as in cosmetics and personal care products. Thus, in this work a multi-syringe chromatographic (MSC) system is proposed for the first time for the dete...
Effects of preservatives on Alicyclobacillus acidoterrestris growth and guaiacol production.Int. J. Food Microbiol. 214 , 145-50, (2015)
Alicyclobacillus acidoterrestris can survive the pasteurization process, multiply in pasteurized juices and produce guaiacol which causes medicinal or antiseptic off-flavors. Chemical preservatives ha...
Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrinsBioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
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公司名:上海化源世纪贸易有限公司
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价格:
联系人:徐经理
产品详情:对羟基苯甲酸乙酯
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¥需询单/1kg
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¥需询单/5mg
联系人:郑雪平
产品详情:Ethylparaben
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥118.0/500g
¥158.0/100mg
联系人:刘佳
产品详情:尼泊金乙酯
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥427.78/1g
联系人:李先生
产品详情:羟苯乙酯;尼泊金乙酯;对羟基苯甲酸乙酯
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相关化合物
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