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美非沙胺

美非沙胺用途

Mefexamide是一种特别的精神刺激剂。

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美非沙胺名称

[ CAS 号 ]:
1227-61-8

[ 中文名 ]:
美非沙胺盐酸盐

[ 英文名 ]:
Mefexamide

[中文别名 ]:

美非沙胺

[英文别名 ]:

Mefexamide hydrochloride
mefexamide

美非沙胺生物活性

[ 描述 ]:

Mefexamide是一种特别的精神刺激剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[相关活性小分子]

美非沙胺物理化学性质

[ 密度 ]:
1.0586 (rough estimate)

[ 沸点 ]:
460.4ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₂₄N₂O₃

[ 分子量 ]:
280.36

[ 闪点 ]:
232.2ºC

[ PSA ]:
50.80000

[ LogP ]:
2.72490

[ 蒸汽压 ]:
1.17E-08mmHg at 25°C

[ 折射率 ]:
1.5800 (estimate)

[ 储存条件 ]:
2-8℃

美非沙胺MSDS

详细MSDS(安全技术说明书)

美非沙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB7175000

CHEMICAL NAME :: Acetamide, N-(2-(diethylamino)ethyl)-2-(p-methoxyphenoxy)-

CAS REGISTRY NUMBER :: 1227-61-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H24-N2-O3

MOLECULAR WEIGHT :: 280.41

WISWESSER LINE NOTATION :: 2N2&2MV1OR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 1,444,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMPYAT Annales Medico-Psychologiques. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1-Series 11, V.2, 1843-1921; V.80- 1922- Volume(issue)/page/year: 123,141,1965

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美非沙胺安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
AB7175000

[ 海关编码 ]:
2924299090

美非沙胺合成路线

详细合成路线

美非沙胺上下游产品

美非沙胺上游产品

美非沙胺下游产品

美非沙胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

美非沙胺文献

[Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants].

Biull. Eksp. Biol. Med. 94(10) , 48-51, (1982)

[Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)].

Ann. Univ. Mariae Curie. Sklodowska. Med. 34 , 259-68, (1979)

[Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].

Z. Rechtsmed. 87(1-2) , 117-27, (1981)

After oral administration of a therapeutic dosage (400 mg) Mefexamide (I), six excretion products were detected in human urine and subsequently identified by GC/MS and TLC: in addition to the unchange...

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