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甲基泼尼松

甲基泼尼松用途

Meprednisone为糖皮质激素,可作用于糖皮质激素受体,强的松的甲基化衍生物。

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甲基泼尼松名称

[ CAS 号 ]:
1247-42-3

[ 中文名 ]:
甲基泼尼松

[ 英文名 ]:
meprednisone

[中文别名 ]:

[英文别名 ]:

16β-Methylprednisone
methylprednisone
deltisonab
Deltisona B
16b-Methylprednisone
Betapred
Betalone
Betapar
meprednisone
Bitanisone

甲基泼尼松生物活性

[ 描述 ]:

Meprednisone为糖皮质激素,可作用于糖皮质激素受体,强的松的甲基化衍生物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

研究领域 >> 代谢疾病

[参考文献]

[1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.

[相关活性小分子]

甲基泼尼松物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
574.4±50.0 °C at 760 mmHg

[ 熔点 ]:
204-206ºC

[ 分子式 ]:
C₂₂H₂₈O₅

[ 分子量 ]:
372.455

[ 闪点 ]:
315.2±26.6 °C

[ 精确质量 ]:
372.193665

[ PSA ]:
91.67000

[ LogP ]:
2.06

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.595

[ 储存条件 ]:
2~8°C

甲基泼尼松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4154090

CHEMICAL NAME :: Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-

CAS REGISTRY NUMBER :: 1247-42-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H28-O5

MOLECULAR WEIGHT :: 372.50

WISWESSER LINE NOTATION :: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 14 mg/kg

SEX/DURATION :: female 16-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6250 ug/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

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甲基泼尼松安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2937210000

甲基泼尼松合成路线

详细合成路线

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甲基泼尼松海关

[ 海关编码 ]: 2937210000