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CGP-42112

CGP-42112用途

CGP-42112(CGP-42112A)是血管紧张素受体AT2激动剂。
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CGP-42112名称

[ CAS 号 ]:
127060-75-7

[ 中文名 ]:
NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE

[ 英文名 ]:
Angiotensin II Receptor Ligand

[英文别名 ]:

CGP-42112生物活性

[ 描述 ]:

CGP-42112(CGP-42112A)是血管紧张素受体AT2激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
研究领域 >> 神经疾病

[溶解度]

体外:

DMSO:≥350mg / mL(332.64 mM)

* “≥”表示可溶,但饱和度未知。


[储备液]

1 mM 0.9504 mL 4.7520 mL 9.5040 mL
5 mM 0.1901 mL 0.9504 mL 1.9008 mL
10 mM 0.0950 mL 0.4752 mL 0.9504 mL

[存储]

粉末 -20°C 3年
  4°C 2年
在溶剂中 -80°C 6月
  -20°C 1月

[运输]

室温;可能会有所不同

[SMILES]

CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CCCCNC([C@H](CCCNC(N)=N)NC(OCC3=CC=CC=C3)=O)=O)NC([C@H](CC4=CC=C(C=C4)O)NC(C5=CC=CN=C5)=O)=O)=O)=O)CCC1)=O

[参考文献]

[1]. Takekoshi K, et al. Angiotensin-II subtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured porcine adrenal medullary chromaffin cells. Biochem Biophys Res Commun. 2000 Jun 7;272(2):544-50.

[2]. Speth RC. [125I]CGP 42112 binding reveals differences between rat brain and adrenal AT2 receptor binding sites. Regul Pept. 1993 Mar 19;44(2):189-97.

[3]. Naveri L, et al. Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319. J Cereb Blood Flow Metab. 1994 Jan;14(1):38-44.

[4]. Heemskerk FM, et al. Quantitative autoradiography of angiotensin II AT2 receptors with [125I]CGP 42112. Brain Res. 1995 Apr 17;677(1):29-38.


[相关活性小分子]

血管紧张素II | AVE 0991 | 一个779 | 曲尼斯特 | PD 123319 二(三氟乙酸盐) | 替米沙坦 | LCZ696 | 奥洛立更 | 非马沙坦 | 血管紧张素 | Sparsentan | C型利钠肽(CNP)(1-22),人 | BIBS 39

[相关文档]

*以上文档由Medchemexpress提供,仅用于科学研究参考。

CGP-42112物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C52H69N13O11

[ 分子量 ]:
1052.185

[ 精确质量 ]:
1051.523926

[ PSA ]:
365.14000

[ LogP ]:
2.38

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.659

CGP-42112MSDS

CGP-42112安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

CGP-42112文献

Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation.

BMC Cancer 11 , 274, (2011)

Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS...

Update on the angiotensin AT(2) receptor.

Curr. Hypertens. Rep. 15(1) , 25-30, (2013)

It is quite well established that activation of the AT(2) receptor (AT(2)R) provides a counter-regulatory role to AT(1)R overactivity, particularly during pathological conditions. Indeed, a potential ...

Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter

Neuroscience 164(3) , 1263-73, (2009)

Endogenous angiotensin (Ang) II and/or an Ang II-derived peptide, acting on Ang type 1 (AT1) and Ang type 2 (AT2) receptors, can carry out part of the nociceptive control modulated by periaqueductal g...


更多文献

推荐生产厂家/供应商:

公司名:上海皓元生物医药科技有限公司

区域:上海市浦东新区

价格:
¥4460.0/5mg ¥1300.0/1mg

联系人:高小姐

产品详情:CGP-42112


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热门化合物

【CGP-42112】化源网提供CGP-42112CAS号127060-75-7,CGP-42112MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询CGP-42112上化源网,专业又轻松。>>电脑版:CGP-42112

标题:【CGP-42112】_CAS号【127060-75-7】_MSDS_化源网 地址:https://m.chemsrc.com/mip/cas/127060-75-7_166977.html