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CGP-42112

CGP-42112用途

CGP-42112(CGP-42112A)是血管紧张素受体AT2激动剂。

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CGP-42112名称

[ CAS 号 ]:
127060-75-7

[ 中文名 ]:
NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE

[ 英文名 ]:
Angiotensin II Receptor Ligand

[英文别名 ]:

MFCD00133611
CGP-42112

CGP-42112生物活性

[ 描述 ]:

CGP-42112(CGP-42112A)是血管紧张素受体AT2激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体

研究领域 >> 神经疾病

[参考文献]

[1]. Takekoshi K, et al. Angiotensin-II subtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured porcine adrenal medullary chromaffin cells. Biochem Biophys Res Commun. 2000 Jun 7;272(2):544-50.

[2]. Speth RC. [125I]CGP 42112 binding reveals differences between rat brain and adrenal AT2 receptor binding sites. Regul Pept. 1993 Mar 19;44(2):189-97.

[3]. Naveri L, et al. Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319. J Cereb Blood Flow Metab. 1994 Jan;14(1):38-44.

[4]. Heemskerk FM, et al. Quantitative autoradiography of angiotensin II AT2 receptors with [125I]CGP 42112. Brain Res. 1995 Apr 17;677(1):29-38.

[相关活性小分子]

CGP-42112物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₅₂H₆₉N₁₃O₁₁

[ 分子量 ]:
1052.185

[ 精确质量 ]:
1051.523926

[ PSA ]:
365.14000

[ LogP ]:
2.38

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.659

[ 储存条件 ]:
2-8℃

CGP-42112MSDS

详细MSDS(安全技术说明书)

CGP-42112安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

CGP-42112文献

Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation.

BMC Cancer 11 , 274, (2011)

Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS...

Update on the angiotensin AT(2) receptor.

Curr. Hypertens. Rep. 15(1) , 25-30, (2013)

It is quite well established that activation of the AT(2) receptor (AT(2)R) provides a counter-regulatory role to AT(1)R overactivity, particularly during pathological conditions. Indeed, a potential ...

Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter

Neuroscience 164(3) , 1263-73, (2009)

Endogenous angiotensin (Ang) II and/or an Ang II-derived peptide, acting on Ang type 1 (AT1) and Ang type 2 (AT2) receptors, can carry out part of the nociceptive control modulated by periaqueductal g...

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