血管紧张素II
血管紧张素II用途
血管紧张素II名称
[ CAS 号 ]:
4474-91-3
[ 中文名 ]:
人血管紧张素II
[ 英文名 ]:
Angiotensin II acetate salt
[中文别名 ]:
[英文别名 ]:
- Angiotensin II
- ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE
- Angiotensin II human
血管紧张素II生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Angiotensin receptor (AT receptor)[1]
[体外研究]
[体内研究]
[动物实验]
[参考文献]
[相关活性小分子]
血管紧张素II物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
809.08°C (rough estimate)
[ 分子式 ]:
C50H71N13O12
[ 分子量 ]:
1046.179
[ 精确质量 ]:
1045.534546
[ PSA ]:
406.34000
[ LogP ]:
2.34
[ 外观性状 ]:
白色至浅黄色粉末
[ 折射率 ]:
1.664
[ 储存条件 ]:
-20°C
血管紧张素II毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BW2165000
- CHEMICAL NAME :
- Angiotensin II, 5-L-isoleucine-
- CAS REGISTRY NUMBER :
- 4474-91-3
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C50-H71-N13-O12
- MOLECULAR WEIGHT :
- 1046.34
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 119 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6109,1990
血管紧张素II安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
BW2165000
血管紧张素II合成路线
血管紧张素II上下游产品
血管紧张素II上游产品
血管紧张素II下游产品
血管紧张素II文献
Can. J. Cardiol. 30(12) , 1700-5, (2014)
Recent evidence suggests that an elevated plasma trimethylamine N-oxide (TMAO) level is associated with an increased risk of adverse cardiovascular events in humans; however, the mechanism is not clea...
IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.J. Cereb. Blood Flow Metab. 34(12) , 1887-97, (2014)
Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the im...
Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.Clin. Sci. 127(1) , 57-63, (2014)
The somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by th...
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¥需询单/1g
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产品详情:Angiotensin II human
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产品详情:Angiotensin II HUMAN
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¥1959.9/100mg
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相关化合物
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