< 生产厂家价格 >

环氧酶素

环氧酶素用途

Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。

点击显示

环氧酶素名称

[ CAS 号 ]:
134381-21-8

[ 中文名 ]:
N-乙酰基-N-甲基-L-异亮氨酰-L-异亮氨酰-N-[(1S)-3-甲基-1-[[(2R)-2-甲基-2-环氧乙烷基]羰基]丁基]-L-苏氨酰胺

[ 英文名 ]:
Epoxomicin

[英文别名 ]:

S7038,BU-4061T
Epoxomicin (BU-4061T)
Epoxomicin

环氧酶素生物活性

[ 描述 ]:

Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体

研究领域 >> 癌症

天然产物 >> 其他

[参考文献]

[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.

[2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.

[3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82.

[4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62.

[5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

[相关活性小分子]

环氧酶素物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
795.7±60.0 °C at 760 mmHg

[ 熔点 ]:
107-109ºC

[ 分子式 ]:
C₂₈H₅₀N₄O₇

[ 分子量 ]:
554.719

[ 闪点 ]:
435.0±32.9 °C

[ 精确质量 ]:
554.367920

[ PSA ]:
157.44000

[ LogP ]:
3.32

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±6.3 mmHg at 25°C

[ 折射率 ]:
1.504

[ 储存条件 ]:
-20°C

环氧酶素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

环氧酶素文献

Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.

Biochim. Biophys. Acta 1853(1) , 183-91, (2015)

In mammalian cells the nuclear-encoded subunits of complex I are imported into mitochondria, where they are assembled with mt-DNA encoded subunits in the complex, or exchanged with pre-existing copies...

Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.

J. Biol. Chem. 285 , 13092-106, (2010)

Carriers of mutations in the cell cycle checkpoint protein kinase ataxia telangiectasia mutated (ATM), which represent 1-2% of the general population, have an increased risk of breast cancer. However,...

The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.

Biochem. J. 456(2) , 173-84, (2013)

The ubiquitin-proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulu...

更多文献