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PD150606

PD150606用途

PD 150606是一个选择性的,能穿过细胞的非肽calpain抑制剂。

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PD150606名称

[ CAS 号 ]:
179528-45-1

[ 中文名 ]:
3-(4-碘苯基-2-疏基-(z)-2-丙酸

[ 英文名 ]:
PD150606

[英文别名 ]:

(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid
PD150606
(2Z)-3-(4-Iodophenyl)-2-sulfanylacrylic acid
(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid

PD150606生物活性

[ 描述 ]:

PD 150606是一个选择性的,能穿过细胞的非肽calpain抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体

研究领域 >> 癌症

[参考文献]

[1]. Squier MK et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9.

[2]. Waters SL et al. Calpains mediate calcium and chloride influx during the late phase of cell injury. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.

[3]. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

[相关活性小分子]

PD150606物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
410.4±45.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₇IO₂S

[ 分子量 ]:
306.120

[ 闪点 ]:
202.0±28.7 °C

[ 精确质量 ]:
305.921143

[ PSA ]:
76.10000

[ LogP ]:
4.25

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.732

[ 储存条件 ]:
2-8℃

PD150606安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H317-H318-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

PD150606文献

Improved performance of aminopropylsilatrane over aminopropyltriethoxysilane as an adhesive film for anchoring gold nanoparticles on silicon surfaces.

J. Nanosci. Nanotechnol. 9 , 2894-901, (2009)

Aminopropylsilatrane (AP-silatrane) was investigated as an adhesive layer for anchoring Au nanoparticles on silicon substrates. We compared the preparation procedure and film quality of the AP-silatra...

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