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C: DTRP-DASP-PRO-DVAL-LEU

C: DTRP-DASP-PRO-DVAL-LEU用途

BQ-123是ETA 内皮素受体拮抗剂,Ki值在ETA和ETB中分别是1.4和1500 nM

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C: DTRP-DASP-PRO-DVAL-LEU名称

[ CAS 号 ]:
136553-81-6

[ 中文名 ]:
C: DTRP-DASP-PRO-DVAL-LEU

[ 英文名 ]:
BQ-123

[英文别名 ]:

d-trp-d-asp-pro-d-val-leu
bq-518
MFCD00133204
BQ-123
m.w. 610.70 c31h42n6o7

C: DTRP-DASP-PRO-DVAL-LEU生物活性

[ 描述 ]:

BQ-123是ETA 内皮素受体拮抗剂,Ki值在ETA和ETB中分别是1.4和1500 nM

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 内皮素受体

研究领域 >> 感染

[参考文献]

[1]. Olgun NS et al. BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicol Appl Pharmacol, 2015 Feb 1;282(3):275-84.

[2]. Kanashiro A et al. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Res, 2015 Jun 12, 1610:12-9.

[3]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.

[相关活性小分子]

C: DTRP-DASP-PRO-DVAL-LEU物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1053.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₁H₄₂N₆O₇

[ 分子量 ]:
610.701

[ 闪点 ]:
591.0±34.3 °C

[ 精确质量 ]:
610.311523

[ PSA ]:
189.80000

[ LogP ]:
-0.10

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.621

[ 储存条件 ]:
-20℃

C: DTRP-DASP-PRO-DVAL-LEUMSDS

C: DTRP-DASP-PRO-DVAL-LEU安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

C: DTRP-DASP-PRO-DVAL-LEU合成路线

C: DTRP-DASP-PRO-DVAL-LEU上下游产品

C: DTRP-DASP-PRO-DVAL-LEU上游产品

C: DTRP-DASP-PRO-DVAL-LEU下游产品

C: DTRP-DASP-PRO-DVAL-LEU文献

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.

Sci. Signal. 8 , ra71, (2015)

Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis, indicating a requirement for NOTCH during maintenance of joint cartilage. However, NOTCH signaling components are substant...

Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation.

Liver Transpl. 20(11) , 1296-305, (2014)

An ischemic-type biliary stricture (ITBS) is a common feature after liver transplantation using donation after cardiac death (DCD) grafts. We compared sequential subnormothermic ex vivo liver perfusio...

Gene expression profiling and endothelin in acute experimental pancreatitis.

World J. Gastroenterol. 18(32) , 4257-69, (2012)

To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.Dibutyltin dichloride (DBTC) is a c...

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