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芦荟苷

芦荟苷用途

Aloin(Aloin-A; Barbaloin-A)是一天然抗肿瘤蒽醌苷,具有铁螯合活性。

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芦荟苷作用

芦荟甙能帮助排出体内污物，净化血液、软化血管，降低血压和血液粘度，促进血液循环，防止动脉硬化和脑溢血的发生。
芦荟甙具有杀菌、消炎解毒、促进伤口愈合等作用。

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芦荟苷名称

[ CAS 号 ]:
1415-73-2

[ 中文名 ]:
巴白洛英

[ 英文名 ]:
Aloin

[中文别名 ]:

[英文别名 ]:

EINECS 215-808-0
barbaloin isomers
BAR-5'-monophosphate
N6-Benzyladenosin-5'-phosphat
Aloin
Benzyl-amp
isobarbaloin
Benzyl-adenosine monophosphate
MFCD00151160
10-(1',5'-Anhydroglucosyl)-aloe-emodin-9-anthrone

芦荟苷生物活性

[ 描述 ]:

Aloin(Aloin-A; Barbaloin-A)是一天然抗肿瘤蒽醌苷,具有铁螯合活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 醌类

[参考文献]

[1]. Pan Q, et al. Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 2013 Jul 12;13(1):69.

[2]. Tabolacci C, et al. Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids. 2013 Jan;44(1):293-300.

[3]. Cui Y, et al. Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice. Arch Pharm Res. 2014 Dec;37(12):1624-33.

[相关活性小分子]

芦荟苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
752.6±60.0 °C at 760 mmHg

[ 熔点 ]:
148-149ºC

[ 分子式 ]:
C₂₁H₂₂O₉

[ 分子量 ]:
418.394

[ 闪点 ]:
268.0±26.4 °C

[ 精确质量 ]:
418.126373

[ PSA ]:
167.91000

[ LogP ]:
1.86

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.741

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

[ 稳定性 ]:
Stable, but light sensitive. Incompatible with bases, strong oxidizing agents. Combustible.

[ 水溶解性 ]:
pyridine: 50 mg/mL, clear, dark red

芦荟苷MSDS

详细MSDS(安全技术说明书)

芦荟苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ6520000

CHEMICAL NAME :: 10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymeth yl)-, 9(10H)-anthracenone-, (+)-

CAS REGISTRY NUMBER :: 1415-73-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H22-O9

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),314,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1298,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1298,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1298,1935

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芦荟苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LZ6520000

芦荟苷合成路线

详细合成路线

芦荟苷上下游产品

芦荟苷上游产品

芦荟苷下游产品

芦荟苷制备

用优质褐煤与烧碱反应[褐煤︰烧碱＝100︰（10～20）（质量比）]，将反应液过滤浓缩干燥，得产品。

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芦荟苷文献

The content of secondary phenol metabolites in pruned leaves of Aloe arborescens, a comparison between two methods: leaf exudates and leaf water extract.

J. Nat. Med. 62(4) , 430-5, (2008)

Aloe arborescens plants, originating from the deserts of South Africa, are grown in the Introduction Garden at Sede Boker in the Negev Desert of Israel. In previous studies, we developed agro-technica...

Determination of aloenin, barbaloin and isobarbaloin in aloe species by micellar electrokinetic chromatography.

J. Chromatogr. B. Biomed. Sci. Appl. 752(1) , 91-7, (2001)

Aloenin, barbaloin and isobarbaloin in JP Aloe, Aloe barbadensis (Aloe vera) and Aloe arborescens Miller var. natalensis Berger (Aloe arborescens Miller) were determined by micellar electrokinetic chr...

Liquid chromatographic determination of barbaloin (aloin) in foods.

J. Assoc. Off. Anal. Chem. 68(3) , 493-4, (1985)

A simple and rapid liquid chromatographic method is described for the determination of barbaloin (aloin, 10-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthraceno ne) in foods. Barbaloin i...

更多文献

芦荟苷

芦荟苷用途

芦荟苷作用

芦荟苷名称

芦荟苷生物活性

芦荟苷物理化学性质

芦荟苷MSDS

详细MSDS(安全技术说明书)

芦荟苷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

芦荟苷安全信息

芦荟苷合成路线

详细合成路线

芦荟苷上下游产品

芦荟苷上游产品

芦荟苷下游产品

芦荟苷制备

芦荟苷文献

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