KN-92 盐酸盐

KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。

信号通路 >> 神经信号通路 >> 蛋白激酶

研究领域 >> 其他

[1]. Rokhlin OW, Guseva NV, Taghiyev AF et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010 Feb;9(3):224-35.

[2]. An P, Zhu JY, Yang Y et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007 Mar 7;13(9):1445-8.

[3]. Gao L, Blair LA, Marshall J. et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.

[4]. Rezazadeh S, Claydon TW, Fedida D. et al. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-

[5]. Anderson ME, Braun AP, Wu Y et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

[6]. Sumi M, Kiuchi K, Ishikawa T et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.

N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羟乙基)-4-甲氧苯磺酰胺磷酸酯盐 | STO-609 | 1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪 | KN-92 磷酸盐 | CaMKII的-IN-1 | MLCK抑制肽18 | Autocamtide 2 | 7-氨基-1-环丙基-3-乙基-1,2,3,4-四氢-2,4-二氧代-吡啶并[2,3-d]嘧啶-6-甲酰胺 | Rimacalib | CaM激酶II(290-309),钙调蛋白拮抗剂 | 美托奋乃酯 | NH125 | PRO-LEU-SER-ARG-THR-LEU-SER-VAL-SER-SER-NH2: PLSRTLSVSS-NH2