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育亨宾

育亨宾用途

Yohimbine是一种有效的和相对非选择性的α2-肾上腺素能受体拮抗剂, IC50值为0.6μM。
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育亨宾名称

[ CAS 号 ]:
146-48-5

[ 中文名 ]:
育亨宾碱

[ 英文名 ]:
Yohimbine

[中文别名 ]:

[英文别名 ]:

育亨宾生物活性

[ 描述 ]:

Yohimbine是一种有效的和相对非选择性的α2-肾上腺素能受体拮抗剂, IC50值为0.6μM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
研究领域 >> 神经疾病

[参考文献]

[1]. Saeed SA, et al. Signaling mechanisms mediated by G-protein coupled receptors in human platelets. Acta Pharmacol Sin. 2004 Jul;25(7):887-892.

[2]. Blanchard RJ, et al. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice. Pharmacol Biochem Behav. 1993 Mar;44(3):673-681.

[3]. Fuller BB, et al. Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol. 2000 Feb;114(2):268-276.


[相关活性小分子]

盐酸异丙肾上腺素 | ICI 118,551盐酸盐 | 盐酸去氧肾上腺素 | 盐酸育亨宾 | 肾上腺素 | 盐酸伊伐布雷定 | 盐酸哌唑嗪 | 盐酸克仑特罗 | 甲磺酸酚妥拉明 | 盐酸胍法辛 | 匹莫齐特 | 盐酸索他洛尔 | 卡维地洛 | 阿替洛尔 | 琥珀酸美托洛尔

育亨宾物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
543.0±50.0 °C at 760 mmHg

[ 熔点 ]:
231-233 °C(lit.)

[ 分子式 ]:
C21H26N2O3

[ 分子量 ]:
354.443

[ 闪点 ]:
282.2±30.1 °C

[ 精确质量 ]:
354.194336

[ PSA ]:
65.56000

[ LogP ]:
2.20

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.661

[ 储存条件 ]:
Store at RT

育亨宾毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZG1000000
CHEMICAL NAME :
Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy-, methyl ester
CAS REGISTRY NUMBER :
146-48-5
BEILSTEIN REFERENCE NO. :
0097276
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C21-H26-N2-O3
MOLECULAR WEIGHT :
354.49
WISWESSER LINE NOTATION :
T F6 D5 C666 EM ON&&TTTJ TQ UVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Behavioral - ataxia Cardiac - change in rate
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 14,1002,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,432,1955
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,432,1955
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,432,1955
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1418,1935
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1418,1935 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
NLETDU Neuroendocrinology Letters. (Brain Research Promotion, D-7400, Tubingen, Germany) V.1- 1979- Volume(issue)/page/year: 12,69,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84715 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)
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育亨宾安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S27-S36/37/39-S45

[ 危险品运输编码 ]:
1544

[ RTECS号 ]:
ZG1000000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

育亨宾合成路线

详细合成路线

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐乾明

产品详情：育亨宾

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Yohimbine

公司名：广东翁江化学试剂有限公司

区域：韶关市翁源县

价格：
￥2400.0/25g ￥1000.0/5g

联系人：朱丽丹

产品详情：育亨宾盐酸盐

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