Dofequidar富马酸盐

Dofequidar 延胡索酸盐(MS-209 延胡索酸盐)是口服活性的喹啉化合物,能抑制 ABCB1/P-gp,ABCC1/MDR-相关蛋白1。

信号通路 >> 跨膜转运 >> P-糖蛋白

研究领域 >> 癌症

[1]. Nakanishi O, et al. Potentiation of the antitumor activity by a novel quinoline compound, MS-209, in multidrug-resistant solid tumor cell lines. Oncol Res. 1997;9(2):61-9.

[2]. Naito M, et al. MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clin Cancer Res. 2002 Feb;8(2):582-8.

[3]. Nokihara H, et al. A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells. Jpn J Cancer Res. 2001 Jul;92(7):785-92.

[4]. Katayama R, et al. Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci. 2009 Nov;100(11):2060-8.

依克立达 | 伐司扑达 | Tariquidar | 唑喹达三盐酸盐 | 利培酮 | 芥子碱硫氰酸盐 | 胡椒碱 | HM30181 | 20(S)-原人参二醇 | 2-(4-甲氧基苯基)-alpha-2-哌啶基-4-喹啉甲醇二盐酸盐 | 泽泻醇F | Dofequidar | 聚乙二醇硬脂酸酯 | 比立考达 | MCI826