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9-芴醇

9-芴醇用途

9-芴醇(9-羟基芴；化合物3)是一种多巴胺(DAT)抑制剂,IC50值为9µM。9-芴醇是作为尾流促进剂开发的化合物的主要代谢产物。9-芴醇在体内显示出唤醒促进活性[1]。

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9-芴醇名称

[ CAS 号 ]:
1689-64-1

[ 中文名 ]:
9-羟基芴

[ 英文名 ]:
9-fluorenol

[中文别名 ]:

[英文别名 ]:

9-Hydroxy fluorene
fluorenol
9H-Fluoren-9-ol
fluoren-9-ol
9-Fluorenol
MFCD00001135
EINECS 216-879-0
9-Hydroxyfluorene
9H-Fluorene-9-ol
fluorene, 9-hydroxy-

9-芴醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[体内研究]

1.19 9-芴醇(100 mg/kg；i.p.)在大鼠体内的药代动力学参数[1]血浆脑Cmax,ng/g 263 4384 tmax,h 2 0.8 AUC0-t,ng h/g 1081 11639

9-芴醇物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
367.5±11.0 °C at 760 mmHg

[ 熔点 ]:
153-154 °C(lit.)

[ 分子式 ]:
C₁₃H₁₀O

[ 分子量 ]:
182.218

[ 闪点 ]:
131.3±11.5 °C

[ 精确质量 ]:
182.073166

[ PSA ]:
20.23000

[ LogP ]:
2.51

[ 外观性状 ]:
灰白色结晶粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.687

[ 储存条件 ]:
2~8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

9-芴醇MSDS

9-芴醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2906299090

9-芴醇合成路线

9-芴醇上下游产品

9-芴醇上游产品

9-芴醇下游产品

9-芴醇海关

[ 海关编码 ]: 2906299090

[ 中文概述 ]:
2906299090 其他芳香醇. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

9-芴醇文献

Rational design of indoleamine 2,3-dioxygenase inhibitors.

J. Med. Chem. 53 , 1172-89, (2010)

Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorit...

A gold nanoparticle-based colorimetric probe for rapid detection of 1-hydroxypyrene in urine.

Analyst 140 , 4662-7, (2015)

Direct and rapid detection of 1-hydroxypyrene (1-OHP) is of great importance owing to its high carcinogenicity, teratogenicity and toxicity. In this study, a simple colorimetric assay for rapid determ...

Assessing hazardous risks of indoor airborne polycyclic aromatic hydrocarbons in the kitchen and its association with lung functions and urinary PAH metabolites in kitchen workers.

Clin. Chim. Acta 452 , 204-13, (2015)

Indoor air pollution is associated with decreased pulmonary function but the relative impact of pollution from kitchen sources on health risks in kitchen workers is not well-known or studied. A study ...

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