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N6-(2-苯乙基)腺苷

N6-(2-苯乙基)腺苷用途

N6-(2-Phenylethyl)adenosine是选择性的A1腺苷受体激动剂。

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N6-(2-苯乙基)腺苷名称

[ CAS 号 ]:
20125-39-7

[ 中文名 ]:
N6-(2-苯基乙基)腺苷

[ 英文名 ]:
N6-(2-Phenylethyl)adenosine

[英文别名 ]:

N6-(2-苯乙基)腺苷生物活性

[ 描述 ]:

N6-(2-Phenylethyl)adenosine是选择性的A1腺苷受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 炎症/免疫

[相关活性小分子]

N6-(2-苯乙基)腺苷物理化学性质

[ 密度 ]:
1.57g/cm3

[ 沸点 ]:
723.5ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₁N₅O₄

[ 分子量 ]:
371.39000

[ 闪点 ]:
391.3ºC

[ 精确质量 ]:
371.15900

[ PSA ]:
125.55000

[ LogP ]:
0.16540

[ 蒸汽压 ]:
5.72E-22mmHg at 25°C

[ 折射率 ]:
1.741

[ 储存条件 ]:
-20°C，密闭，干燥

N6-(2-苯乙基)腺苷MSDS

详细MSDS(安全技术说明书)

N6-(2-苯乙基)腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

N6-(2-苯乙基)腺苷合成路线

详细合成路线

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N6-(2-苯乙基)腺苷文献

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.

Nucleic Acids Res. 39 , 4373-86, (2011)

The carbon catabolite repressor protein 4 (Ccr4)-Negative on TATA (Not) complex controls gene expression at two levels. In the nucleus, it regulates the basal transcription machinery, nuclear receptor...

Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.

Bioorg. Med. Chem. 12 , 2021-2034, (2004)

We synthesized phenyl ring-substituted analogues of N(6)-(1S,2R)-(2-phenyl-1-cyclopropyl)adenosine, which is highly potent in binding to the human A(3)AR with a Ki value of 0.63 nM. The effects of the...

Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice.

Eur. J. Pharmacol. 371 , 137-145, (1999)

We have studied the effects of selective and non-selective adenosine receptor agonists and antagonists in audiogenic-seizure-sensitive DBA/2 mice, an animal model of generalized reflex epilepsy. With ...

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