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5-氟胞嘧啶

5-氟胞嘧啶用途

Flucytosine(5-Fluorocytosine, 5-FC, Ancobon)是抗真菌化合物。
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5-氟胞嘧啶名称

[ CAS 号 ]:
2022-85-7

[ 中文名 ]:
5-氟胞嘧啶

[ 英文名 ]:
5-Flucytosine

[中文别名 ]:

[英文别名 ]:

5-氟胞嘧啶生物活性

5-氟胞嘧啶物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
298ºC

[ 熔点 ]:
298-300 °C (dec.)(lit.)

[ 分子式 ]:
C4H4FN3O

[ 分子量 ]:
129.092

[ 精确质量 ]:
129.033844

[ PSA ]:
71.77000

[ LogP ]:
-2.36

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0492mmHg at 25°C

[ 折射率 ]:
1.649

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Light Sensitive

[ 水溶解性 ]:
1.5g/100mL (25 ºC)

5-氟胞嘧啶MSDS

5-氟胞嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA6040000
CHEMICAL NAME :
Cytosine, 5-fluoro-
CAS REGISTRY NUMBER :
2022-85-7
LAST UPDATED :
199801
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C4-H4-F-N3-O
MOLECULAR WEIGHT :
129.11
WISWESSER LINE NOTATION :
T6MVNJ DZ EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1080 mg/kg/10D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3811 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3336 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
8 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967- Volume(issue)/page/year: 146,253,1976 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6122 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1033 (estimated) No. of Female Employees: 480 (estimated)
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5-氟胞嘧啶安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22-S24/25-S45-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
HA6040000

[ 海关编码 ]:
2933599090

5-氟胞嘧啶上下游产品

5-氟胞嘧啶制备

1.由5-氟尿嘧啶经氯化、氨化、水解而得。1.氯化将5-氟尿嘧啶和三氯氧磷加入氯化锅,搅拌,控制在20℃以下滴加N,N-二甲基苯胺。滴加完毕,升温到110℃左右反应2h。冷至室温,放至冰盐水中冰解,维持15℃搅拌1h。过滤,水洗,得2,4-二氯-5-氟嘧啶。2.氨化将2,4-二氯-5-氟嘧啶溶解在乙醇中,搅拌,控制在35℃以下滴加氨水。滴毕,降温至25℃反应3h,减压回收乙醇至干,加水搅拌升温到20℃。过滤,用水洗涤结晶,干燥,得出4-氨基-2-氯-5-氟嘧啶。3.水解将4-氨基-2-氯-5-氟嘧啶和盐酸混合,搅拌升温至90-95℃,反应2h后,减压浓缩至干,加水溶解结晶,加活性炭脱色。过滤,滤液用氨水调pH至7-8,放置过夜。甩滤,用水洗涤结晶,经精制即得氟胞密啶。总收率50%。该法的起始原料为抗癌药氟尿嘧啶[51-21-8],也可以采用氟尿嘧啶的前体,即2-甲氧基-4-羟基-5-氟嘧啶为原料,经氯化,氨化,水解制备氟胞嘧啶,收率70%。将上述前体加入甲苯中,再加入二甲基苯胺,加热至50-60℃,滴加三氯氧磷。然后105-110℃反应3h。冷却至室温,将反应液加入甲苯和水的混合液中,在25-40℃搅拌。分出甲苯层,水层用甲苯提出取,将提出取液与甲苯层合并,先减压回收甲苯,再收集86-90℃(2.66kPa)馏分即得2-甲氧基-4-氯-5-氟嘧啶。将上步氯化产物与无水甲醇加入压力釜中,在室温下通氨至饱和,缓缓升温使压力达到0.5MPa,搅拌反应过夜。冷到室温出料,经处理得2-甲氧基-4-氨基-5-氟嘧啶,熔点189-191℃。将其与30%盐酸在100-105℃反应3h。水解物减压蒸干,用水溶解残留物,加氨水碱化到pH8.5,冷却至5℃以下,过滤,得氟胞嘧啶粗品,用水重结晶即得成品。

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5-氟胞嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-氟胞嘧啶文献

The mannoprotein TIR3 (CAGL0C03872g) is required for sterol uptake in Candida glabrata.

Biochim. Biophys. Acta 1851(2) , 141-51, (2015)

Sterol uptake in the pathogenic fungus, Candida glabrata, occurs via the sterol transporter, CgAus1p. Azole inhibition of sterol biosynthesis can under certain circumstances be reversed by adding exog...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...


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公司名:上海吉至生化科技有限公司

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¥348.0/100g ¥238.0/25g

联系人:刘佳

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公司名:上海源溪生物科技有限公司

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公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

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公司名:上海创赛科技有限公司

区域:上海市嘉定区

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¥36.0/1g ¥60.0/5g ¥75.0/25g ¥256.0/100g

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公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

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¥71.9/25g ¥255.9/100g ¥29.9/1g ¥56.9/5g

联系人:阿拉丁李高志

产品详情:5-氟胞嘧啶


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相关化合物

【5-氟胞嘧啶】化源网提供5-氟胞嘧啶CAS号2022-85-7,5-氟胞嘧啶MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询5-氟胞嘧啶上化源网,专业又轻松。>>电脑版:5-氟胞嘧啶

标题:5-氟胞嘧啶_MSDS_用途_密度_5-氟胞嘧啶CAS号【2022-85-7】_化源网 地址:https://m.chemsrc.com/mip/cas/2022-85-7_1084314.html