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长川霉素

长川霉素用途

Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物,具有很强的免疫抑制剂。

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长川霉素名称

[ CAS 号 ]:
104987-12-4

[ 中文名 ]:
长川霉素

[ 英文名 ]:
Ascomycin

[中文别名 ]:

子囊霉素

[英文别名 ]:

immunomycin
Ascomycin
changchuanmycin
Isopamphos
Immucillin-H
MFCD00467131
Fodosine

长川霉素生物活性

[ 描述 ]:

Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物,具有很强的免疫抑制剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

天然产物 >> 其他

[参考文献]

[1]. Hatanaka H, Kino T, Miyata S, FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601.

[2]. Teutsch M, Higer M, Wang D, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. Int Immunol. 1995 Mar;7(3):381-92.

[3]. Mollison KW, Fey TA, Krause RA, Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology. 1998 Feb 6;125(2-3):169-81.

[相关活性小分子]

长川霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
868.3±75.0 °C at 760 mmHg

[ 熔点 ]:
153-157ºC

[ 分子式 ]:
C₄₃H₆₉NO₁₂

[ 分子量 ]:
792.008

[ 闪点 ]:
478.9±37.1 °C

[ 精确质量 ]:
791.481995

[ PSA ]:
178.36000

[ LogP ]:
3.81

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water

长川霉素MSDS

详细MSDS(安全技术说明书)

长川霉素安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H332-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
UN 1648 3 / PGII

[ WGK德国 ]:
3

[ RTECS号 ]:
KD4185000

[ 海关编码 ]:
29419090

长川霉素文献

Highly specific targeting of human leukocytes using gold nanoparticle-based biologically active conjugates.

J. Biomed. Nanotechnol. 10(7) , 1259-66, (2014)

In this study we demonstrate for the first time a new approach for highly specific targeting of viable human leukocytes by functionalised gold nanoconjugates made on the basis of citrate-stabilised go...

Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.

Clin. Exp. Allergy 35(5) , 554-9, (2005)

Chronic urticaria is a common skin disorder, which causes considerable morbidity. In approximately 40% of cases, patients have an autoimmune disorder in which functional antibodies cause degranulation...

The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding.

J. Immunol. 177(10) , 7050-8, (2006)

Cyclosporin A (CsA) is a fungus-derived cyclic undecapeptide with potent immunosuppressive activity. Its analog, cyclosporin H (CsH), lacks immunosuppressive function but can act as an antagonist for ...

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