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水飞蓟宾A

水飞蓟宾A用途

Silibinin为抗癌和化疗预防化合物,能抑制细胞增殖和迁移。

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水飞蓟宾A名称

[ CAS 号 ]:
22888-70-6

[ 中文名 ]:
水飞蓟宾

[ 英文名 ]:
Silymarin

[中文别名 ]:

[英文别名 ]:

flavobin
EINECS 245-302-5
SILYBIN A
SILYBININ
silliver
Silibinin
Silybin
Silybum Substance E6
silybine
MFCD00872186

水飞蓟宾A生物活性

[ 描述 ]:

Silibinin为抗癌和化疗预防化合物,能抑制细胞增殖和迁移。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

天然产物 >> 黄酮类化合物

[参考文献]

[1]. Woo SM, et al. Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. Chem Biol Interact. 2014 Jan 16;211C:36-43.

[2]. Kim TH, et al. Silibinin induces cell death through ROS-dependent down-regulation of Notch-1/ERK/Akt signaling in human breast cancer cells. J Pharmacol Exp Ther. 2014 Jan 28.

[3]. Zhang S, et al. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One. 2013 Dec 27;8(12):e83699.

[4]. Khan AQ, et al. Silibinin Inhibits Tumor Promotional Triggers and Tumorigenesis Against Chemically Induced Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Possible Role of Oxidative Stress and Inflammation. Nutr Cancer. 2013 Dec 23.

[5]. Khazim K, et al. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700.

[相关活性小分子]

水飞蓟宾A物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
793.0±60.0 °C at 760 mmHg

[ 熔点 ]:
164-174°C

[ 分子式 ]:
C₂₅H₂₂O₁₀

[ 分子量 ]:
482.436

[ 闪点 ]:
274.5±26.4 °C

[ 精确质量 ]:
482.121307

[ PSA ]:
155.14000

[ LogP ]:
2.59

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.684

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

水飞蓟宾AMSDS

水飞蓟宾A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2981770

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphen yl)-2- (hydroxymethyl)-1,4-benzodioxin-6-yl)-3,5,7-trihydrox y-, (2R-(2-alpha,3-beta,6(2R*,3R*)))-

CAS REGISTRY NUMBER :: 22888-70-6

LAST UPDATED :: 199506

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H22-O10

MOLECULAR WEIGHT :: 482.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1056 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,404,1983

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,404,1983

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水飞蓟宾A安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39-S24/25-S22

[ 危险品运输编码 ]:
3172

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ2981770

[ 海关编码 ]:
2932999099

水飞蓟宾A合成路线

水飞蓟宾A上下游产品

水飞蓟宾A上游产品

水飞蓟宾A下游产品

水飞蓟宾A海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

水飞蓟宾A文献

High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry - a suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts.

J. Chromatogr. A. 1394 , 137-47, (2015)

Extraction parameters, chemical fingerprint, and the single compounds' activity levels were considered for the selection of active botanicals. For an initial survey, the total bioactivity (i.e., total...

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

J. Pharm. Pharmacol. 66(9) , 1339-46, (2014)

The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-...

Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits.

Eur. J. Drug Metab. Pharmacokinet. 39(4) , 277-81, (2014)

Silibinin, a major constituent of silymarin, is widely used for its hepatoprotective effects. This study investigated the effect of silibinin on the pharmacokinetics of oral nitrendipine in rabbits. I...

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