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长春质碱

长春质碱用途

Catharanthine是一种由长春花提取的生物碱,能抑制烟碱受体介导的隔膜收缩,IC50为59.6μM

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长春质碱名称

[ CAS 号 ]:
2468-21-5

[ 中文名 ]:
长春碱

[ 英文名 ]:
Catharanthine

[中文别名 ]:

[英文别名 ]:

Catharanthine Sulphate
catharintine
CatharanthineSulfateBase
catharantine
(+)-3,4-Didehydrocoronaridine
Catharanthine
catharanthin
UNII-WT0YJV846J
catharinthine
MFCD01753356

长春质碱生物活性

[ 描述 ]:

Catharanthine是一种由长春花提取的生物碱,能抑制烟碱受体介导的隔膜收缩,IC50为59.6μM

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. Pereira, D.M., et al., Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine, 2010. 17(8-9): p. 646-52.

[2]. Prakash, V. and S.N. Timasheff, Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry, 1991. 30(3): p. 873-80.

[3]. Williams, J.A., Catharanthine: a novel stimulator of pancreatic enzyme release. Cell Tissue Res, 1978. 192(2): p. 277-84.

[4]. Arias, H.R., et al., Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors. Neurochem Int, 2010. 57(2): p. 153-61.

[相关活性小分子]

长春质碱物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
491.5±45.0 °C at 760 mmHg

[ 熔点 ]:
138-140ºC

[ 分子式 ]:
C₂₁H₂₄N₂O₂

[ 分子量 ]:
336.427

[ 闪点 ]:
251.1±28.7 °C

[ 精确质量 ]:
336.183777

[ PSA ]:
45.33000

[ LogP ]:
4.05

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.663

[ 储存条件 ]:
库房低温通风干燥

长春质碱MSDS

长春质碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NH6732500

CHEMICAL NAME :: Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2-alpha,5-beta,6-alpha,18-beta)-

CAS REGISTRY NUMBER :: 2468-21-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H24-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1213,1977

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长春质碱安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

长春质碱合成路线

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长春质碱文献

Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.

J. Pharmacol. Exp. Ther. 345(3) , 383-92, (2013)

Catharanthine is a constituent of anticancer vinca alkaloids. Its cardiovascular effects have not been investigated. This study compares the in vivo hemodynamic as well as in vitro effects of catharan...

The leaf epidermome of Catharanthus roseus reveals its biochemical specialization.

Plant Cell 20(3) , 524-42, (2008)

Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and...

Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry.

J. Sep. Sci. 34 , 2885-2892, (2011)

Catharanthus roseus is an important dicotyledonous medicinal plant that contains various anticancer components, such as vinblastine (VLB) and its monomeric precursors (vindoline and catharanthine). A ...

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