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6-异丙氧基-9-氧杂蒽酮-2-羧酸

6-异丙氧基-9-氧杂蒽酮-2-羧酸用途

AH 6809是EP和DP受体拮抗剂，对人EP1，EP2，EP3-III和DP1受体有相近的亲和力。

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6-异丙氧基-9-氧杂蒽酮-2-羧酸名称

[ CAS 号 ]:
33458-93-4

[ 中文名 ]:
6-异丙氧基-9-氧杂蒽酮-2-羧酸

[ 英文名 ]:
AH 6809

[英文别名 ]:

6-Isopropoxy-9-oxo-9H-xanthene-2-carboxylic acid
Tocris-0671
AH 6809
6-Isopropoxy-9-oxoxanthene-2-carboxylic acid

6-异丙氧基-9-氧杂蒽酮-2-羧酸生物活性

[ 描述 ]:

AH 6809是EP和DP受体拮抗剂,对人EP1,EP2,EP3-III和DP1受体有相近的亲和力。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. http://www.millipore.com/publications.nsf/a73664f9f981af8c852569b9005b4eee/cae2c825891fb78e85257b19005fa865/$FILE/HTS099C%20ep1%20datasheet%20121212.pdf

[2]. Keery RJ, et al. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol. 1988 Jul;94(3):745-54.

[3]. Capehart AA, et al. Effects of a putative prostaglandin E2 antagonist, AH6809, on chondrogenesis in serum-free cultures of chick limb mesenchyme. J Cell Physiol. 1991 Jun;147(3):403-11.

[4]. Piazuelo E, et al. Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma. Curr Cancer Drug Targets. 2012 Feb;12(2):132-43.

[5]. Rutkai I, et al. Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes. Cardiovasc Res. 2009 Jul 1;83(1):148-54.

[相关活性小分子]

6-异丙氧基-9-氧杂蒽酮-2-羧酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
514.2±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₇H₁₄O₅

[ 分子量 ]:
298.290

[ 闪点 ]:
192.9±23.6 °C

[ 精确质量 ]:
298.084137

[ PSA ]:
76.74000

[ LogP ]:
3.91

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
2-8℃

6-异丙氧基-9-氧杂蒽酮-2-羧酸MSDS

详细MSDS(安全技术说明书)

6-异丙氧基-9-氧杂蒽酮-2-羧酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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