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N-乙酰基-L-羟脯氨酸

N-乙酰基-L-羟脯氨酸用途

Oxaceprol是抗炎症的药物,常使用在骨关节炎中。

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N-乙酰基-L-羟脯氨酸名称

[ CAS 号 ]:
33996-33-7

[ 中文名 ]:
N-乙酰-L-4-羟基脯氨酸

[ 英文名 ]:
Oxaceprol

[中文别名 ]:

[英文别名 ]:

AHP-200
trans-1-Acetyl-4-hydroxy-1-proline
Jonctum
N-Acetyl-L-hydroxyproline
Oxaceprol
L-Proline, 1-acetyl-4-hydroxy-, (4R)-
(2S,4R)-N-acetyl-4-hydroxyproline
CO-61
trans-l-prolin
(4R)-1-Acetyl-4-hydroxy-L-proline

N-乙酰基-L-羟脯氨酸生物活性

[ 描述 ]:

Oxaceprol是抗炎症的药物,常使用在骨关节炎中。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 感染

[参考文献]

[1]. Ionac M et al. Oxaceprol, an atypical inhibitor of inflammation and joint damage. Pharmacol Res, 1996 Jun, 33(6):367-73.

[2]. Harris A et al. Effects of oxaceprol on the microcirculation in ischemia/reperfusion injury. Eur J Med Res, 1998 Apr 8, 3(4):182-8.

[相关活性小分子]

N-乙酰基-L-羟脯氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
442.1±45.0 °C at 760 mmHg

[ 熔点 ]:
132-133 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₁₁NO₄

[ 分子量 ]:
173.167

[ 闪点 ]:
221.2±28.7 °C

[ 精确质量 ]:
173.068802

[ PSA ]:
77.84000

[ LogP ]:
-2.04

[ 外观性状 ]:
白色细晶体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
室温

N-乙酰基-L-羟脯氨酸MSDS

详细MSDS(安全技术说明书)

N-乙酰基-L-羟脯氨酸安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R41

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

N-乙酰基-L-羟脯氨酸合成路线

详细合成路线

N-乙酰基-L-羟脯氨酸上下游产品

N-乙酰基-L-羟脯氨酸上游产品

N-乙酰基-L-羟脯氨酸下游产品

N-乙酰基-L-羟脯氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-乙酰基-L-羟脯氨酸文献

Oxaceprol, an atypical inhibitor of inflammation, reduces leukocyte adherence in mouse antigen-induced arthritis.

Acta Orthop. Scand. 72(3) , 293-8, (2001)

Oxaceprol (N-acetyl-L-hydroxyproline), an atypical inhibitor of inflammation, is an established drug forjoint disease without serious side-effects. Recent studies have emphasized that oxaceprol has an...

Determination of oxaceprol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.

J. Pharm. Biomed. Anal. 54(1) , 173-8, (2011)

A sensitive method for the quantification of oxaceprol in rat plasma using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. Sample pretreatment involved a simp...

[Assessment of the placebo effect of symptomatic slow-acting anti-arthritics].

Presse Med. 27(5) , 211-4, (1998)

Assess the importance of the mid-term placebo effect of symptomatic slow acting drugs given for osteoarthritis.We analyzed six controlled trials available in the literature. Trial duration ranged from...

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