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盐酸赛庚啶

盐酸赛庚啶用途

Cyproheptadine hydrochloride sesquihydrate是一种抗组胺剂, 且是血清素和组胺2拮抗剂。

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盐酸赛庚啶作用

抗凝血、抗过敏类新药。可用于荨麻疹、湿疹、过敏性和接触性皮炎、皮肤瘙痒等过敏反应。另外，临床发现，赛庚啶还有治疗流行性腮腺炎等多种新用途，研究表明盐酸赛庚啶的H1拮抗作用比扑尔敏强5倍以上。

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盐酸赛庚啶名称

[ CAS 号 ]:
41354-29-4

[ 中文名 ]:
盐酸赛庚啶

[ 英文名 ]:
Cyproheptadine hydrochloride

[中文别名 ]:

[英文别名 ]:

MFCD00012538
Cyproheptadine hydrochloride sesquihydrate
Cyproheptadine hydrochloride
EINECS 213-535-1
Periactin
Cyproheptadine (hydrochloride sesquihydrate)

盐酸赛庚啶生物活性

[ 描述 ]:

Cyproheptadine hydrochloride sesquihydrate是一种抗组胺剂, 且是血清素和组胺2拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 神经疾病

[相关活性小分子]

盐酸赛庚啶物理化学性质

[ 沸点 ]:
440.1ºC at 760 mmHg

[ 熔点 ]:
165 °C (dec.)(lit.)

[ 分子式 ]:
C₂₁H₂₁N_.3/₂H₂O_.HCl

[ 分子量 ]:
350.88

[ 闪点 ]:
194.5ºC

[ PSA ]:
12.47000

[ LogP ]:
5.37350

[ 外观性状 ]:
白色至略淡黄色结晶固体

[ 储存条件 ]:
室温

[ 水溶解性 ]:
ethanol: soluble

盐酸赛庚啶MSDS

详细MSDS(安全技术说明书)

盐酸赛庚啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
TM7050000

盐酸赛庚啶文献

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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