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左旋甲基多巴

左旋甲基多巴用途

L-(-)-_alpha_-Methyldopa水合物是_alpha_-肾上腺素能受体激动剂。

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左旋甲基多巴名称

[ CAS 号 ]:
41372-08-1

[ 中文名 ]:
L-甲基多巴

[ 英文名 ]:
Methyldopa Sesquihydrate

[中文别名 ]:

[英文别名 ]:

a-Methyl-L-dopa
α-Methyl-L-dopa
Dopegyt
L-(-)-b-(3,4-Dihydroxyphenyl)-a-methylalanine
L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine
L-(-)-a-Methyl-b-(3,4-dihydroxyphenyl)alanine
a-Methyl Dopa
L-α-Methyl-DOPA
α-Methyl dopa
EINECS 209-089-2

左旋甲基多巴生物活性

[ 描述 ]:

L-(-)-_alpha_-Methyldopa水合物是_alpha_-肾上腺素能受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 心血管疾病

[参考文献]

[1]. BAILA MR, et al. The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension. Dia Med. 1962 Dec 6;34:2422-4.

[相关活性小分子]

左旋甲基多巴物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
441.6±45.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₁₀H₁₃NO_4.3/₂H₂O

[ 分子量 ]:
238.24

[ 闪点 ]:
220.9±28.7 °C

[ PSA ]:
113.01000

[ LogP ]:
0.13

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.

[ 水溶解性 ]:
0.1-1 g/100 mL at 23 ºC

左旋甲基多巴MSDS

详细MSDS(安全技术说明书)

左旋甲基多巴毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2860000

CHEMICAL NAME :: L-Tyrosine, 3-hydroxy-alpha-methyl-, sesquihydrate

CAS REGISTRY NUMBER :: 41372-08-1

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H13-N-O4.3/2H2-O

MOLECULAR WEIGHT :: 238.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17500 mg/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68250 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - other changes

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 604 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2980 mg/kg

SEX/DURATION :: male 65 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

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左旋甲基多巴安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R20/21:Harmful by inhalation and in contact with skin . R36/37/38:Irritating to eyes, respiratory system and skin . R42/43:May cause sensitization by inhalation and skin contact . R65:Harmful: May cause lung damage if swallowed.

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YP2860000

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