异秦皮啶

异秦皮啶用途

Isofraxidin 来自 Acanthopanax senticosus 的一种香豆素成分,抑制 MMP-7 表达和人肝癌细胞侵袭。Isofraxidin 作用于肝癌细胞,抑制 ERK1/2 磷酸化。Isofraxidin 减弱 iNOS 和 COX-2 表达,Isofraxidin 还抑制 TLR4/髓样分化蛋白 2 (MD-2) 复合物的形成。

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异秦皮啶名称

[ CAS 号 ]:
486-21-5

[ 中文名 ]:
异嗪皮啶

[ 英文名 ]:
Isofraxidin

[中文别名 ]:

[英文别名 ]:

isoferaxidin
7-Hydroxy-6,8-dimethoxy-2H-chromen-2-one
iso-Fraxidin
Phytodolor
6,8-dimethoxy-7-hydroxycoumarin
MFCD00221757
7-Hydroxy-6,8-dimethoxy-2H-1-benzopyran-2-one
7-Hydroxy-6,8-dimethoxy coumarin
2H-1- Benzopyran-2-one, 7-hydroxy-6,8-dimethoxy-
Coumarin,7-hydroxy-6,8-dimethoxy

异秦皮啶生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> Toll样受体(TLR)

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

信号通路 >> 代谢酶/蛋白酶 >> MMP

[ 靶点 ]

COX-2

TLR4

MMP-7

[体外研究]

异黄酮通过抑制肝癌细胞ERK1/2磷酸化,在无毒水平上抑制MMP-7的表达和体外细胞侵袭[1]。异黄酮竞争性地抑制TLR4/MD-2复合物的形成,从而抑制TLR4/NF-κB信号级联。异黄酮在治疗骨关节炎(OA)中具有潜在的作用[2]。

[参考文献]

[1]. Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33(10):1716-22.

[2]. Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9(11):5641-5652.

异秦皮啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
452.1±45.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₁₁H₁₀O₅

[ 分子量 ]:
222.194

[ 闪点 ]:
183.2±22.2 °C

[ 精确质量 ]:
222.052826

[ PSA ]:
68.90000

[ LogP ]:
1.31

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
slightly soluble

异秦皮啶MSDS

详细MSDS(安全技术说明书)

异秦皮啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100020

CHEMICAL NAME :: 2H-1-Benzopyran-2-one, 7-hydroxy-6,8-dimethoxy-

CAS REGISTRY NUMBER :: 486-21-5

BEILSTEIN REFERENCE NO. :: 0202652

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H10-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1330,1968

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异秦皮啶安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ 安全声明 (欧洲) ]:
S23-S28-S28A-S25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
OY2300000

异秦皮啶上下游产品

异秦皮啶上游产品

异秦皮啶下游产品

异秦皮啶文献

Determination of isofraxidin and astilbin by HPLC in rat plasma and its application after orally administration the extract of Sarcandra glabra.

Pak. J. Pharm. Sci. 26(1) , 1-6, (2013)

Sarcandra glaber is a common traditional Chinese medicine used to treat psoriasis and other infectious diseases, isofraxidin and astilbin are the main components of it. In order to study the pharmacok...

Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.

J. Nat. Med. 65(3-4) , 417-23, (2011)

Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer's disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome o...

Simultaneous determination of protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin in Acanthopanax senticosus Harms by HPLC-DAD.

Biol. Pharm. Bull. 29(3) , 532-4, (2006)

A high performance liquid chromatography (HPLC) method was developed for the first time to quantify simultaneously the six major active ingredients in Acanthopanax senticosus (Rupr. et Maxim.) Harms, ...

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