< 生产厂家价格 >

莪术醇; 姜黄醇

莪术醇; 姜黄醇用途

莪术醇(Curcumol)是一抗癌活性的倍半萜醇天然化合物。

点击显示

莪术醇; 姜黄醇名称

[ CAS 号 ]:
4871-97-0

[ 中文名 ]:
莪术醇

[ 英文名 ]:
Curcumol

[中文别名 ]:

[英文别名 ]:

莪术醇; 姜黄醇生物活性

[ 描述 ]:

莪术醇(Curcumol)是一抗癌活性的倍半萜醇天然化合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Tang QL, et al. Curcumol induces apoptosis in SPC-A-1 human lung adenocarcinoma cells and displays anti-neoplastic effects in tumor bearing mice. Asian Pac J Cancer Prev. 2015;16(6):2307-12.

[2]. Chen G, et al. Curcumol induces HSC-T6 cell death through suppression of Bcl-2: involvement of PI3K and NF-κB pathways. Eur J Pharm Sci. 2014 Dec 18;65:21-8.

[3]. Yu M, et al. Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway. Biochem Biophys Res Commun. 2014 May 2;447(2):364-70.

[相关活性小分子]

莪术醇; 姜黄醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
334.5±42.0 °C at 760 mmHg

[ 熔点 ]:
141-142ºC

[ 分子式 ]:
C₁₅H₂₄O₂

[ 分子量 ]:
236.350

[ 闪点 ]:
134.7±22.1 °C

[ 精确质量 ]:
236.177628

[ PSA ]:
29.46000

[ LogP ]:
3.25

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.526

[ 储存条件 ]:
室温

莪术醇; 姜黄醇安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
29321900

莪术醇; 姜黄醇合成路线

详细合成路线

莪术醇; 姜黄醇上下游产品

莪术醇; 姜黄醇上游产品

莪术醇; 姜黄醇下游产品

莪术醇; 姜黄醇文献

Isolation and identification of phase 1 metabolites of curcumol in rats.

Drug Metab. Dispos. 38(11) , 2014-22, (2010)

Curcumol is one of the major components of the essential oil of Curcuma wenyujin with the structure of a guaiane-type sesquiterpenoid hemiketal. It exhibits clear antitumor, antihepatic fibrosis, anti...

Subunit-specific inhibition of glycine receptors by curcumol.

J. Pharmacol. Exp. Ther. 343(2) , 371-9, (2012)

Emerging evidence has suggested that inhibitory glycine receptors (GlyRs) are an important molecular target in the treatment of numerous neurological disorders. Rhizoma curcumae is a medicinal plant w...

Chemical constituents from the radix of Curcuma wenyujin.

Fitoterapia 80(6) , 374-6, (2009)

Phytochemical study on the ethanol extract of the radixes of Curcuma wenyujin Y. H. Chen et C. Ling led to the isolation of three new compounds curcuminol F (1) curcuminol G (2) and wenyujinoside (3) ...

更多文献