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硝呋太尔

硝呋太尔用途

Nifuratel(NF 113, SAP 113)是广谱抗生素,具有抗细菌、真菌和毛滴虫的活性。

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硝呋太尔名称

[ CAS 号 ]:
4936-47-4

[ 中文名 ]:
尼莫唑

[ 英文名 ]:
Nifuratel

[中文别名 ]:

[英文别名 ]:

Polmiror
UNII:U60U6P08SP
nf113
EINECS 225-576-2
Magmilor
Nifuratel
Methylmercadone
Tydantil
Macmiror
Omnes

硝呋太尔生物活性

[ 描述 ]:

Nifuratel(NF 113, SAP 113)是广谱抗生素,具有抗细菌、真菌和毛滴虫的活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 寄生物

天然产物 >> 生物碱

研究领域 >> 感染

[参考文献]

[1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40.

[2]. Nijevitch AA, et al. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy withnifuratel to furazolidone. Aliment Pharmacol Ther. 2005 Nov 1;22(9):881-7.

[3]. Nijevitch AA, et al. Nifuratel-containing initial anti-Helicobacter pylori triple therapy in children. Helicobacter. 2007 Apr;12(2):132-5.

[相关活性小分子]

硝呋太尔物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
423.6±53.0 °C at 760 mmHg

[ 熔点 ]:
176-178°C

[ 分子式 ]:
C₁₀H₁₁N₃O₅S

[ 分子量 ]:
285.276

[ 闪点 ]:
210.0±30.9 °C

[ 精确质量 ]:
285.041931

[ PSA ]:
126.16000

[ LogP ]:
0.27

[ 外观性状 ]:
新鲜的黄色结晶或黄色粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.666

[ 储存条件 ]:
-20°C Freezer

硝呋太尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3590000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino )-

CAS REGISTRY NUMBER :: 4936-47-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H11-N3-O5-S

MOLECULAR WEIGHT :: 285.30

WISWESSER LINE NOTATION :: T5OJ BNW E1UN- AT5NVOTJ E1S1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ng/plate

REFERENCE :: MIGIA6 Minerva Ginecologia. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1949- Volume(issue)/page/year: 31,263,1979

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硝呋太尔安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ WGK德国 ]:
3