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香草乙酮

香草乙酮用途

Apocynin是选择性的 NADPH-氧化酶抑制剂,IC50 为10 μM。

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香草乙酮名称

[ CAS 号 ]:
498-02-2

[ 中文名 ]:
4'-羟基-3'-甲氧基苯乙酮

[ 英文名 ]:
Acetovanillone

[中文别名 ]:

[英文别名 ]:

4'-hydroxy-3'-methoxyacetophenone
MFCD00008747
Acetovanillone
Apocynin
Ethanone, 1-(4-hydroxy-3-methoxyphenyl)-
1-(4-Hydroxy-3-methoxyphenyl)ethanone
EINECS 207-854-5

香草乙酮生物活性

[ 描述 ]:

Apocynin是选择性的 NADPH-氧化酶抑制剂,IC50 为10 μM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 酚类

研究领域 >> 癌症

[参考文献]

[1]. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102.

[2]. Stefanska J, et al. Mediators Inflamm, 2008, 106507.

[3]. Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81(5):636-48.

[相关活性小分子]

香草乙酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
297.5±0.0 °C at 760 mmHg

[ 熔点 ]:
112-115 °C(lit.)

[ 分子式 ]:
C₉H₁₀O₃

[ 分子量 ]:
166.174

[ 闪点 ]:
125.5±15.8 °C

[ 精确质量 ]:
166.062988

[ PSA ]:
46.53000

[ LogP ]:
1.39

[ 外观性状 ]:
淡黄色至棕色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
soluble in hot water

香草乙酮MSDS

详细MSDS(安全技术说明书)

香草乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM8800000

CHEMICAL NAME :: Acetophenone, 4'-hydroxy-3'-methoxy-

CAS REGISTRY NUMBER :: 498-02-2

BEILSTEIN REFERENCE NO. :: 0637373

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

WISWESSER LINE NOTATION :: 1VR DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 400 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 119,273,1983

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香草乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
AM8800000

[ 海关编码 ]:
2942000000

香草乙酮上下游产品

香草乙酮上游产品

香草乙酮下游产品

香草乙酮制备

1. 由对-α-羟乙基邻甲氧基苯酚进行氧化制取。或由乙酸愈创木酚在醋酐中，与氯化锌共同加热制取。

2. 烟草：BU，56；FC，BU，OR，18。

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香草乙酮海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

香草乙酮文献

Mutual enhancement between high-mobility group box-1 and NADPH oxidase-derived reactive oxygen species mediates diabetes-induced upregulation of retinal apoptotic markers.

J. Physiol. Biochem. 71 , 359-72, (2015)

The expression of the proinflammatory cytokine high-mobility group box-1 (HMGB1) is upregulated in epiretinal membranes and vitreous fluid from patients with proliferative diabetic retinopathy (PDR) a...

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.

Biochim. Biophys. Acta 1851(3) , 290-8, (2015)

We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the...

Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells.

Pharm. Biol. 52(11) , 1451-9, (2014)

Abstract Background: Carbamazepine, which was developed primarily for the treatment of epilepsy, is now also useful for the treatment of non-epileptic disorders and inflammatory hyperalgesia. However,...

更多文献

香草乙酮

香草乙酮用途

香草乙酮名称

香草乙酮生物活性

香草乙酮物理化学性质

香草乙酮MSDS

详细MSDS(安全技术说明书)

香草乙酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

香草乙酮安全信息

香草乙酮上下游产品

香草乙酮上游产品

香草乙酮下游产品

香草乙酮制备

香草乙酮海关

香草乙酮文献

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