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氯拉扎尼

氯拉扎尼用途

Chlorazanil 是一种三嗪衍生物,也是一种新型非毒性利尿剂。

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氯拉扎尼名称

[ CAS 号 ]:
500-42-5

[ 中文名 ]:
氯拉扎尼

[ 英文名 ]:
Chlorazanil

[中文别名 ]:

氯苯二胺三嗪

[英文别名 ]:

N2-(4-Chlor-phenyl)-[1,3,5]triazin-2,4-diyldiamin
Chlorazinil
Neo-Urofort
Chlorazanil
Daquin
Orpizin
Triazurol
Chloroazinal
Neurofort
Diurazine

氯拉扎尼生物活性

[ 描述 ]:

Chlorazanil 是一种三嗪衍生物,也是一种新型非毒性利尿剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Thevis M, et al. Formation of the diuretic chlorazanil from the antimalarial drug proguanil--implications for sports drug testing. J Pharm Biomed Anal. 2015 Nov 10;115:208-13.

[相关活性小分子]

氯拉扎尼物理化学性质

[ 密度 ]:
1.483g/cm3

[ 沸点 ]:
457.2ºC at 760mmHg

[ 分子式 ]:
C₉H₈ClN₅

[ 分子量 ]:
221.64600

[ 闪点 ]:
230.3ºC

[ 精确质量 ]:
221.04700

[ PSA ]:
76.72000

[ LogP ]:
2.50500

[ 折射率 ]:
1.72

[ 储存条件 ]:
2-8℃

氯拉扎尼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY3150500

CHEMICAL NAME :: s-Triazine, 2-amino-4-(p-chloroanilino)-

CAS REGISTRY NUMBER :: 500-42-5

BEILSTEIN REFERENCE NO. :: 0016503

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H8-Cl-N5

MOLECULAR WEIGHT :: 221.67

WISWESSER LINE NOTATION :: T6N CN ENJ BZ DMR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 79,5064,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,350,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,225,1964

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氯拉扎尼安全信息

[ 海关编码 ]:
2933699090

氯拉扎尼上下游产品

氯拉扎尼上游产品

氯拉扎尼下游产品

氯拉扎尼海关

[ 海关编码 ]: 2933699090

[ 中文概述 ]:
2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%