酒石酸肾上腺素

酒石酸肾上腺素用途

L-Epinephrine bitartrate是α-adrenergic和β-adrenergic的激动剂。L-Epinephrine是由肾上腺髓质分泌的激素。

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酒石酸肾上腺素作用

体外活性：与未治疗的对照眼相比，将12微升体积的1％L-肾上腺素硼酸盐溶液施用于12只猴子的一只眼睛的角膜上，分别使通过虹膜和睫状体的血流减少59％和20％。肾上腺素是一种直接作用的拟交感神经药α-肾上腺素能和β-肾上腺素能激动剂，具有环腺苷一磷酸介导的，复杂的，对许多靶器官的双向药理作用。在年轻的成年大鼠中，肾上腺素的内源性释放促进了对于时间相关事件的稳定记忆形成。肾上腺素通过增加调节记忆所需的血糖水平来增强年轻成年大鼠的记忆。肾上腺素是心肺复苏（CPR）期间用于逆转心脏骤停的主要药物。肾上腺素通过α-1-肾上腺素受体激动剂作用增加CPR期间的动脉血压和冠状动脉灌注。

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酒石酸肾上腺素名称

[ CAS 号 ]:
51-42-3

[ 中文名 ]:
(-)-肾上腺素 (+)-酒石酸氢盐

[ 英文名 ]:
Epinephrine bitartrate

[中文别名 ]:

[英文别名 ]:

L-Adrenaline D-hydrogentartrate
L-Epinephrine D-hydrogentartrate
(-)-Epinephrine (+)-bitartrate salt
EINECS 200-097-1
MFCD00035077
(-)-Epinephrine (+)-bitartrate
L-(-)-Epinephrine-(+)-bitartrate
Epinephrine bitartrate
(-)-Epinephrine bitartrate
EPINEPHRINE HYDROGEN TARTRATE

酒石酸肾上腺素生物活性

[ 描述 ]:

L-Epinephrine bitartrate是α-adrenergic和β-adrenergic的激动剂。L-Epinephrine是由肾上腺髓质分泌的激素。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[体内研究]

与未处理的对照眼相比,将12微升体积的1％L-肾上腺素硼酸盐溶液施用于12只猴子的一只眼睛的角膜上,分别使通过虹膜和睫状体的血流减少59％和20％[ 1]。肾上腺素是一种直接作用的拟交感神经药α-肾上腺素能和β-肾上腺素能激动剂,具有环腺苷一磷酸介导的,复杂的,对许多靶器官的双向药理作用[2]。在年轻成年大鼠中,肾上腺素的内源性释放促进了对于时间相关事件的稳定记忆形成。肾上腺素通过增加调节记忆所需的血糖水平来增强年轻成年大鼠的记忆[3]。肾上腺素是心肺复苏(CPR)期间用于逆转心脏骤停的主要药物。肾上腺素通过α-1-肾上腺素能受体激动剂作用增加CPR期间的动脉血压和冠状动脉灌注[4]。

[参考文献]

[1]. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980 May;19(5):487-91.

[2]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44.

[3]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.

[4]. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.

[相关活性小分子]

酒石酸肾上腺素物理化学性质

[ 沸点 ]:
413.1ºC at 760 mmHg

[ 熔点 ]:
~155 °C (dec.)

[ 分子式 ]:
C₁₃H₁₉NO₉

[ 分子量 ]:
333.291

[ 闪点 ]:
207.9ºC

[ 精确质量 ]:
333.105988

[ PSA ]:
187.78000

[ 外观性状 ]:
白色固体

[ 折射率 ]:
-16.5 ° (C=2, H2O)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with bases, oxidizing agents, iron, iron salts, copper, copper alloys.

[ 水溶解性 ]:
H2O: soluble

酒石酸肾上腺素MSDS

详细MSDS(安全技术说明书)

酒石酸肾上腺素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO3500000

CAS REGISTRY NUMBER :: 51-42-3

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C9-H13-N-O3.C4-H6-O6

MOLECULAR WEIGHT :: 333.33

WISWESSER LINE NOTATION :: QR BQ DYQ1M1 &QVYQYQVQ -L -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 82 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Cardiac - cardiomyopathy including infarction

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1780 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Cardiac - other changes Gastrointestinal - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 mg/kg/42D-I

TOXIC EFFECTS :: Cardiac - other changes Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2400 ug/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 1 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3514,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82895 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82895 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1721 (estimated) No. of Female Employees: 1639 (estimated)

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酒石酸肾上腺素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R28;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S28-S36/37-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
DO3500000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

酒石酸肾上腺素文献

An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures.

Microb. Cell Fact. 14 , 113, (2015)

Membrane proteins are important drug targets in many human diseases and gathering structural information regarding these proteins encourages the pharmaceutical industry to develop new molecules using ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

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酒石酸肾上腺素

酒石酸肾上腺素用途

酒石酸肾上腺素作用

酒石酸肾上腺素名称

酒石酸肾上腺素生物活性

酒石酸肾上腺素物理化学性质

酒石酸肾上腺素MSDS

详细MSDS(安全技术说明书)

酒石酸肾上腺素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

酒石酸肾上腺素安全信息

酒石酸肾上腺素文献

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