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HC-067047

HC-067047用途

HC-067047是一种有效,选择性的 TRPV4 拮抗剂,抑制人,大鼠,小鼠TRPV4的IC50 分别为48 nM,133 nM,17 nM。

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HC-067047名称

[ CAS 号 ]:
883031-03-6

[ 中文名 ]:
HC-067047

[ 英文名 ]:
HC 067047

[英文别名 ]:

HC-067047

HC-067047生物活性

[ 描述 ]:

HC-067047是一种有效,选择性的 TRPV4 拮抗剂,抑制人,大鼠,小鼠TRPV4的IC50 分别为48 nM,133 nM,17 nM。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 癌症

[ 靶点 ]

IC50: 48 nM (human TRPV4), 133 nM (rat TRPV4), 17 nM (mouse TRPV4)[1]

[参考文献]

[1]. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.

[相关活性小分子]

辣椒碱 | 辣椒平 | 5-(N-乙基-N-异丙基)阿米洛利 | 氯化二亚苯基碘鎓 | 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 | AMG9810 | GSK1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG 517 | 3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺 | 冰素 | ML204

HC-067047物理化学性质

[ 分子式 ]:
C₂₆H₂₈F₃N₃O₂

[ 分子量 ]:
471.51500

[ 精确质量 ]:
471.21300

[ PSA ]:
49.99000

[ LogP ]:
5.77880

[ 储存条件 ]:
2-8℃

HC-067047MSDS

详细MSDS(安全技术说明书)

HC-067047安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

HC-067047文献

Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(8) , R945-55, (2014)

Transient receptor potential vanilloid family type 4 (TRPV4) channels are expressed in central neuroendocrine neurons and have been shown to be polymodal in other systems. We previously reported that ...

Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.

Invest. Ophthalmol. Vis. Sci. 56(2) , 1396-405, (2015)

Aqueous humor inflow falls 50% during sleeping hours without proportional fall in IOP, partly reflecting reduced outflow facility. The mechanisms underlying outflow facility cycling are unknown. One o...

Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung.

Thorax 69(12) , 1080-9, (2014)

COPD is an inflammatory disease usually associated with cigarette smoking (CS) with an increasing global prevalence and no effective medication. Extracellular ATP is increased in the COPD affected lun...

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