氟西汀
氟西汀用途
氟西汀名称
[ CAS 号 ]:
54910-89-3
[ 中文名 ]:
氟西汀
[ 英文名 ]:
Fluoxetine
[中文别名 ]:
[英文别名 ]:
- Adofen
- MFCD00072041
- AURORA KA-7692
- Reneuron
- Fluctin
- Foxetin
- Fluoxeren
- Fluval
- fluoxetina
- EINECS 611-209-7
氟西汀生物活性
[ 描述 ]:
[ 相关类别 ]:
[体外研究]
[体内研究]
[动物实验]
[参考文献]
[相关活性小分子]
氟西汀物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
395.1±42.0 °C at 760 mmHg
[ 熔点 ]:
158ºC
[ 分子式 ]:
C17H18F3NO
[ 分子量 ]:
309.326
[ 闪点 ]:
192.8±27.9 °C
[ 精确质量 ]:
309.134064
[ PSA ]:
21.26000
[ LogP ]:
4.09
[ 外观性状 ]:
无色至浅黄色至黄色至棕色液体或油
[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C
[ 折射率 ]:
1.511
[ 储存条件 ]:
室温
氟西汀毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DA8326855
- CHEMICAL NAME :
- Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
- CAS REGISTRY NUMBER :
- 54910-89-3
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C17-H18-F3-N-O
- MOLECULAR WEIGHT :
- 309.36
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 60 mg/kg/21W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 153,134,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 72 mg/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year: 10,343,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 16800 ug/kg/6W-I
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - antipsychotic Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 156,681,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2 mg/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 156,681,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 825 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,1178,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 121 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,1178,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 464 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,1178,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 87500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,1178,1990 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 80 mg/kg
- SEX/DURATION :
- female 13-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 280,138,1997
氟西汀安全信息
[ 危害码 (欧洲) ]:
C,Xi
[ 风险声明 (欧洲) ]:
R34:Causes burns. R36/37:Irritating to eyes and respiratory system . R36/37/38:Irritating to eyes, respiratory system and skin .
[ 安全声明 (欧洲) ]:
S23-S26-S27-S36/37/39-S45-S37/39
[ 危险品运输编码 ]:
UN 3265 8/PG 2
[ WGK德国 ]:
2
[ 包装等级 ]:
III
[ 危险类别 ]:
8
[ 海关编码 ]:
29036990
氟西汀上下游产品
氟西汀上游产品
氟西汀下游产品
氟西汀制备
方法1:苯乙酮和多聚甲醛及甲胺进行Mannich反应,生成β-甲氨基苯丙酮的盐酸盐和双[N-(2-苯甲酰基)乙基]甲胺的盐酸盐,氟西汀的制备只需前者,而后者是副产物。
叔胺副产物可通过水蒸气蒸馏,使其分解为有用的仲胺。
将前面得到的仲胺加到碳酸钾的水溶液中,再加入乙醇溶解,分批加入硼氢化钾,加毕继续反应。减压蒸除乙醇,剩余液先用乙醚后用氯仿萃取。萃取液合并,盐水洗至Ph值8.0,干燥。过滤,减压蒸出有机溶剂。残留物用己烷重结晶,得N-甲基-3-苯基-3-羟基丙胺,收率89.7%。将其溶于N,N-二甲基乙酰胺(DMAC)中,加入氢化钠,缓慢升温至70℃保温。再加入碘化钾和对氯三氟甲苯,升至90℃反应。加水稀释,乙醚萃取。萃取液用盐水洗至Ph值8.0,干燥,过滤,通氯化氢气体至Ph值1.0,放置。滤集结晶,烘干,用乙酸乙酯重结晶,得盐酸氟西汀,收率80%,熔点152~153℃。
方法2:β-甲氨基苯丙酮用硼烷来还原为醇后,用氯化亚砜氯化,生成3-甲氨基-1-苯基-1-丙醇,接着和对三氟苯酚钠反应,得到氟西汀。
方法3:8.1g溴化氰溶于500ml苯和50ml甲苯中,在5℃、搅拌和氮气鼓泡保护下,滴加12.146g N,N-二甲基-3-(4-三氟甲基苯氧基)-3-苯基丙胺溶于40ml苯的溶液。反应温度允许升至室温,并在氮气气氛中继续搅拌过夜。加入100rnl苯,反应液用水洗2次,再用1mol/L。硫酸水溶液洗1次,然后用水洗至中性。干燥,减压蒸去溶剂,得9.5g油状的N-甲基-N-氰基-3-(4-三氟甲基苯氧基)-3-苯基丙胺。
100g氢氧化钾、85ml水、400ml乙二醇和9.50g N-甲基-N-氰基-3-(4-三氟甲基苯氧基)-3-苯基丙胺一起,回流(130℃)20h,然后冷却。加入500ml水后,用3份500ml乙醚萃取。合并萃取液,水洗后,用2mol/L盐酸水溶液萃取。分出萃取液后,有机层先后用1次2mol/L盐酸水溶液、3次水和1次饱和氯化钠水溶液进行萃取。所有水溶性萃取液合并,用5mol/L氢氧化钠水溶液碱化。因氟西汀不溶于碱性水溶液,故而析出。用乙醚萃取3次,合并萃取液,用饱和氯化钠水溶液洗后,干燥,减压蒸去乙醚,得6.3g氟西汀。
氟西汀海关
[ 海关编码 ]: 29036990
相关药品:
推荐生产厂家/供应商:
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥144.9/1g
¥5149.9/100g
¥4999.0/100g
¥需询单/1g
联系人:阿拉丁李高志
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相关化合物
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