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盐酸丙氧卡因

盐酸丙氧卡因用途

Propoxycaine盐酸盐是一种局部麻醉剂, 结合并抑制电压门控钠通道, 抑制脉冲起始和传导所需的离子通量, 从而导致感觉的丢失。

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盐酸丙氧卡因名称

[ CAS 号 ]:
550-83-4

[ 中文名 ]:
盐酸丙氧卡因

[ 英文名 ]:
Propoxycaine (hydrochloride)

[英文别名 ]:

Pravocaine hydrochloride
EINECS 208-988-7
WIN 3459
Propoxycaine HCl
Ravocaine hydrochloride
Blockain
Propoxycaine Hyrochloride
Propoxycaine hydrochloride
Propoxycaine (hydrochloride)

盐酸丙氧卡因生物活性

[ 描述 ]:

Propoxycaine盐酸盐是一种局部麻醉剂, 结合并抑制电压门控钠通道, 抑制脉冲起始和传导所需的离子通量, 从而导致感觉的丢失。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 神经疾病

[相关活性小分子]

盐酸丙氧卡因物理化学性质

[ 沸点 ]:
434.4ºC at 760mmHg

[ 分子式 ]:
C₁₆H₂₇ClN₂O₃

[ 分子量 ]:
330.85000

[ 闪点 ]:
216.5ºC

[ 精确质量 ]:
330.17100

[ PSA ]:
64.79000

[ LogP ]:
3.93940

[ 储存条件 ]:
2-8℃

盐酸丙氧卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3066000

CHEMICAL NAME :: Benzoic acid, 4-amino-2-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride

CAS REGISTRY NUMBER :: 550-83-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H26-N2-O3.Cl-H

MOLECULAR WEIGHT :: 330.90

WISWESSER LINE NOTATION :: 3OR CZ FVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7417 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958