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双水杨酸酯

双水杨酸酯用途

Salsalate是一种非类固醇消炎药 (NSAID)。

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双水杨酸酯名称

[ CAS 号 ]:
552-94-3

[ 中文名 ]:
双水杨酸酯

[ 英文名 ]:
Salsalate

[中文别名 ]:

[英文别名 ]:

Disalcid
EINECS 209-027-4
2-[(2-Hydroxybenzoyl)oxy]benzoic acid
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
2-(2-hydroxybenzoyl)oxybenzoic acid
2-salicyloyloxy-benzoic acid
Salicylsalicylic acid
Saloxium
Diacesal
Salicylic Acid Bimolecular Ester

双水杨酸酯生物活性

[ 描述 ]:

Salsalate是一种非类固醇消炎药 (NSAID)。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

双水杨酸酯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
482.9±25.0 °C at 760 mmHg

[ 熔点 ]:
139-151 °C

[ 分子式 ]:
C₁₄H₁₀O₅

[ 分子量 ]:
258.226

[ 闪点 ]:
188.0±16.7 °C

[ 精确质量 ]:
258.052826

[ PSA ]:
83.83000

[ LogP ]:
3.05

[ 外观性状 ]:
晶体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.646

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
水解

双水杨酸酯MSDS

详细MSDS(安全技术说明书)

双水杨酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2080000

CHEMICAL NAME :: Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester

CAS REGISTRY NUMBER :: 552-94-3

BEILSTEIN REFERENCE NO. :: 2590908

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H10-O5

MOLECULAR WEIGHT :: 258.24

WISWESSER LINE NOTATION :: QVR BOVR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2229 mg/kg/2Y-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 107,116,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1101,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 665 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 29,250,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80509 No. of Facilities: 105 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3179 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80509 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 629 (estimated) No. of Female Employees: 291 (estimated)

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双水杨酸酯安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
37/39-26

[ 危险品运输编码 ]:
3077.0

[ RTECS号 ]:
DH2080000

[ 海关编码 ]:
2918230000

双水杨酸酯合成路线

详细合成路线

双水杨酸酯上下游产品

双水杨酸酯上游产品

双水杨酸酯下游产品

双水杨酸酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

双水杨酸酯文献

Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.

J. Pharm. Biomed. Anal. 111 , 333-43, (2015)

Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a...

Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.

Br. J. Pharmacol. 172 , 5293-305, (2016)

Salsalate (salicylsalicylic acid) is an anti-inflammatory drug that was recently found to exert beneficial metabolic effects on glucose and lipid metabolism. Although its utility in the prevention and...

Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.

J. Pharmacol. Exp. Ther. 339(3) , 896-904, (2011)

Type 2 diabetes mellitus (T2DM) arises owing to insulin resistance and β-cell dysfunction. Chronic inflammation is widely identified as a cause of T2DM. The Goto-Kakizaki (GK) rat is a spontaneous rod...

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