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甜菜碱盐酸盐

甜菜碱盐酸盐用途

Betaine hydrochloride 是许多食物中发现的天然化合物,也是一种可维持正常 DNA 甲基化模式的活性甲基供体。

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甜菜碱盐酸盐名称

[ CAS 号 ]:
590-46-5

[ 中文名 ]:
盐酸甜菜碱

[ 英文名 ]:
Betaine Hydrochloride

[中文别名 ]:

[英文别名 ]:

(Trimethylammonio)acetate hydrochloride
EINECS 209-683-1
Acinorm
lycine hydrochloride
ACIDOL
Betaine Hydrochloride
Achylin
Betaine, hydrochloride
Pluchine
BET HCL

甜菜碱盐酸盐生物活性

[ 描述 ]:

Betaine hydrochloride 是许多食物中发现的天然化合物,也是一种可维持正常 DNA 甲基化模式的活性甲基供体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 其他

[体外研究]

发现随着MTT试验暴露于增加的甜菜碱盐酸盐水平,HeLa细胞的增殖被显着抑制(p <0.05)。低剂量组(<5 mg/mL)中S期细胞的百分比明显高于高剂量组,而Sub-G1期的比例则相反(p <0.05)。高浓度的甜菜碱盐酸盐(> 5.0 mg/mL)显着促进HeLa细胞的凋亡(p <0.01)。低剂量组SOD活性略高于对照组(p <0.05),促凋亡基因Bax,P53,Caspase 3和凋亡抑制基因Bcl-2的表达存在明显的同步性和相关性。响应细胞凋亡诱导刺激,p53和细胞周期蛋白D1可以在G1/S或S/G2检查点阻断细胞周期而被激活[1]。

[体内研究]

补充甜菜碱盐酸盐可减轻肝脏与体重的比例。当在含酒精的液体饮食中加入甜菜碱盐酸盐时,肝脏甘油三酯(TG)积聚和肝损伤均显着降低。甜菜碱盐酸盐补充减少慢性酒精摄入引起的附睾脂肪垫质量损失。甜菜碱盐酸盐补充剂可防止S-腺苷同型半胱氨酸(SAM)的消耗,并减少S-腺苷同型半胱氨酸(SAH)的增加,从而改善脂肪组织的甲基化状态[2]。

[细胞实验]

通过MTT测定评估盐酸甜菜碱的细胞毒性作用。简而言之，将5×103 HeLa或MCF-10A细胞/孔接种在96孔板中并培养过夜。然后，向每个孔中加入不同浓度的甜菜碱盐酸盐（0至100mg / mL），并在孵育后24,48,72和96小时进行MTT测定。根据制造商的说明[1]，使用超氧化物歧化酶测定试剂盒检测Cu / Zn-SOD活性。

[动物实验]

在该研究中使用重25±0.5g的雄性C57BL / 6小鼠。将动物随机分配到四组（每组n = 6至8），并且通过逐步进食程序将改良的Lieber-DeCarli酒精（AF）或等热量麦芽糖糊精对照液体饮食（PF）配对喂养5周。乙醇含量从总热量的30％开始，并在上周逐渐增加至36％。甜菜碱盐酸盐作为补充剂在液体饮食（PF和AF）中以0.5％（w / v）的浓度与醇同时施用。所有动物都可随意饮食和饮水。在实验结束时，小鼠在被剥夺食物4小时后被杀死，并且收集血浆，肝脏和附睾脂肪垫样品用于测定[2]。

[参考文献]

[1]. Guo Y, et al. Betaine Effects on Morphology, Proliferation, and p53-induced Apoptosis of HeLa Cervical Carcinoma Cells in Vitro. Asian Pac J Cancer Prev. 2015;16(8):3195-201.

[2]. Dou X, et al. Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease. Br J Pharmacol. 2014 Sep;171(17):4073-86.

[相关活性小分子]

甜菜碱盐酸盐物理化学性质

[ 密度 ]:
1 g/cm3

[ 熔点 ]:
241-242 °C(lit.)

[ 分子式 ]:
C₅H₁₂ClNO₂

[ 分子量 ]:
153.607

[ 精确质量 ]:
153.055649

[ PSA ]:
37.30000

[ 外观性状 ]:
无色至白色晶体

[ 储存条件 ]:
室温

[ 水溶解性 ]:
64.7 g/100 mL (25 ºC)

甜菜碱盐酸盐MSDS

详细MSDS(安全技术说明书)

甜菜碱盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP3136000

CHEMICAL NAME :: Ammonium, (carboxymethyl)trimethyl-, chloride

CAS REGISTRY NUMBER :: 590-46-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H12-N-O2.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80382 No. of Facilities: 112 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 3807 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80382 No. of Facilities: 204 (estimated) No. of Industries: 11 No. of Occupations: 23 No. of Employees: 4634 (estimated) No. of Female Employees: 2460 (estimated)

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甜菜碱盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi, Xn

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S39-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BP3136000

[ 海关编码 ]:
2923900090

甜菜碱盐酸盐合成路线

详细合成路线

甜菜碱盐酸盐上下游产品

甜菜碱盐酸盐上游产品

甜菜碱盐酸盐下游产品

甜菜碱盐酸盐海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

甜菜碱盐酸盐文献

Sulfur amino acid metabolism in Zucker diabetic fatty rats.

Biochem. Pharmacol. 96 , 256-66, (2015)

The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

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