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地巴唑

地巴唑用途

Bendazol 是一种降压药物,也可以增强 NO 合成酶 (NO synthase) 在肾小球和集合小管中的活性。

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地巴唑名称

[ CAS 号 ]:
621-72-7

[ 中文名 ]:
地巴唑

[ 英文名 ]:
bendazol

[中文别名 ]:

2-苄基苯并咪唑

[英文别名 ]:

EINECS 210-703-6
bendazol
2-benzylbenzIMIDAZOLE
MFCD00022680
2-Benzyl-1H-benzimidazole
1H-Benzimidazole, 2-(phenylmethyl)-
bendazole

地巴唑生物活性

[ 描述 ]:

Bendazol 是一种降压药物,也可以增强 NO 合成酶 (NO synthase) 在肾小球和集合小管中的活性。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 心血管疾病

[ 靶点 ]

NO synthase[1]

[参考文献]

[1]. Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361.

[相关活性小分子]

地巴唑物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
453.5±24.0 °C at 760 mmHg

[ 熔点 ]:
187ºC

[ 分子式 ]:
C₁₄H₁₂N₂

[ 分子量 ]:
208.258

[ 闪点 ]:
252.1±9.3 °C

[ 精确质量 ]:
208.100052

[ PSA ]:
28.68000

[ LogP ]:
3.93

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.680

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

地巴唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6206000

CHEMICAL NAME :: Benzimidazole, 2-benzyl-

CAS REGISTRY NUMBER :: 621-72-7

BEILSTEIN REFERENCE NO. :: 0159495

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H12-N2

MOLECULAR WEIGHT :: 208.28

WISWESSER LINE NOTATION :: T56 BM DNJ C1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (1),44,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(6),25,1990

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 504 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,829,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2292473

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (5),26,1983 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 2 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967

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地巴唑安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2942000000

地巴唑合成路线

详细合成路线

地巴唑上下游产品

地巴唑上游产品

地巴唑下游产品

地巴唑制备

【方法一】
邻苯二胺和苯乙酸经环合而得。先将邻苯二胺和盐酸混合加热溶解，加苯乙酸后搅拌升温，在108-110℃脱水5h。再分步升温反应，直至240℃时停止加热。用液碱调节pH至9-10，50℃下过滤，得地巴唑。将地巴唑加水溶解，用盐酸调pH至4.6-4.8，加活性炭脱色得地巴唑盐酸盐。

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地巴唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

地巴唑

地巴唑用途

地巴唑名称

地巴唑生物活性

地巴唑物理化学性质

地巴唑毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

地巴唑安全信息

地巴唑合成路线

详细合成路线

地巴唑上下游产品

地巴唑上游产品

地巴唑下游产品

地巴唑制备

地巴唑海关

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