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茶碱乙酸

茶碱乙酸用途

Acefylline 是一个腺苷受体拮抗剂。

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茶碱乙酸名称

[ CAS 号 ]:
652-37-9

[ 中文名 ]:
茶碱乙酸

[ 英文名 ]:
Acefylline

[中文别名 ]:

[英文别名 ]:

EINECS 211-490-2
MFCD00022832
7-Theophyllinylacetic acid
7-Theophyllineacetic acid
Acefylline
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid
Carboxymethyltheophylline
acetyloxytheophylline
theophylline-7-acetic acid
acephylline

茶碱乙酸生物活性

[ 描述 ]:

Acefylline 是一个腺苷受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 癌症

[ 靶点 ]

adenosine receptor[1]

[参考文献]

[1]. Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14(1):31-6.

[相关活性小分子]

茶碱乙酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
555.7±56.0 °C at 760 mmHg

[ 熔点 ]:
270-272 °C

[ 分子式 ]:
C₉H₁₀N₄O₄

[ 分子量 ]:
238.200

[ 闪点 ]:
289.9±31.8 °C

[ 精确质量 ]:
238.070206

[ PSA ]:
99.12000

[ LogP ]:
-0.49

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.714

[ 储存条件 ]:
Refrigerator

茶碱乙酸MSDS

详细MSDS(安全技术说明书)

茶碱乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO7451300

CHEMICAL NAME :: Purine-7-acetic acid, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-

CAS REGISTRY NUMBER :: 652-37-9

BEILSTEIN REFERENCE NO. :: 0279221

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H10-N4-O4

MOLECULAR WEIGHT :: 238.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2733 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

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茶碱乙酸安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ WGK德国 ]:
2

[ RTECS号 ]:
UO7451300