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氯喹那多

氯喹那多用途

Chlorquinaldol是一种抗菌剂, 用于治疗局部皮肤病症和阴道感染。

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氯喹那多名称

[ CAS 号 ]:
72-80-0

[ 中文名 ]:
5,7-二氯-8-羟基喹哪啶

[ 英文名 ]:
chlorquinaldol

[中文别名 ]:

[英文别名 ]:

5,7-Dichloro-2-methyl-8-quinolinol
5,7-Dichloro-8-hydroxyquinaldine
2-methyl-5,7-dichloro-8-hydroxyquinoline
5,7-Dichloro-8-quinaldinol
Clorquinaldol
Chloroquinaldol
EINECS 200-789-3
Gynotherax
5,7-dichloro-2-methylquinolin-8-ol
2-methylchloroxine

氯喹那多生物活性

[ 描述 ]:

Chlorquinaldol是一种抗菌剂, 用于治疗局部皮肤病症和阴道感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[相关活性小分子]

氯喹那多物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
350.7±37.0 °C at 760 mmHg

[ 熔点 ]:
108-112 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₇Cl₂NO

[ 分子量 ]:
228.075

[ 闪点 ]:
165.9±26.5 °C

[ 精确质量 ]:
226.990463

[ PSA ]:
33.12000

[ LogP ]:
4.21

[ 外观性状 ]:
黄色至棕色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Insoluble

氯喹那多MSDS

氯喹那多毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5600000

CHEMICAL NAME :: 8-Quinolinol, 5,7-dichloro-2-methyl-

CAS REGISTRY NUMBER :: 72-80-0

BEILSTEIN REFERENCE NO. :: 0156683

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H7-Cl2-N-O

MOLECULAR WEIGHT :: 228.08

WISWESSER LINE NOTATION :: T66 BNJ C1 GG IG JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

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氯喹那多安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
VC5600000

[ 海关编码 ]:
2933499090

氯喹那多合成路线

氯喹那多上下游产品

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氯喹那多海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氯喹那多文献

Purity determination of gynalgin bactericidal tablets with HPLC method.

Acta Pol. Pharm. 70(1) , 51-8, (2013)

The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6...

[Allergies to 8-hydroxyquinoline derivatives].

Derm. Beruf Umwelt. 36(3) , 86-90, (1988)

Evaluation of our standardized test results from 1972 to 1983 indicated Vioform allergies in 1.2% of all cases and Sterosan allergies in 1.1%. Our results are within the spectrum found in the literatu...

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Antimicrob. Agents Chemother. 51 , 1105-6, (2007)

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/...

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