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五味子醇甲

五味子醇甲用途

五味子醇甲(Schisandrin)是具有抗癌和抗炎症等生物活性的天然化合物。

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五味子醇甲名称

[ CAS 号 ]:
7432-28-2

[ 中文名 ]:
五味子素

[ 英文名 ]:
Schisandrol A

[中文别名 ]:

[英文别名 ]:

Schizandrin
Schisandrol A
schizandra
Schisandrol

五味子醇甲生物活性

[ 描述 ]:

五味子醇甲(Schisandrin)是具有抗癌和抗炎症等生物活性的天然化合物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 炎症/免疫

天然产物 >> 苯丙酸类

[参考文献]

[1]. Park JH, et al. Schizandrin inhibits fibrosis and epithelial-mesenchymal transition in transforming growth factor-β1-stimulated AML12 cells. Int Immunopharmacol. 2015 Apr;25(2):276-84.

[2]. Guo LY, et al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 2008 Sep 4;591(1-3):293-9.

[相关活性小分子]

五味子醇甲物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
576.7±50.0 °C at 760 mmHg

[ 熔点 ]:
128-129ºC

[ 分子式 ]:
C₂₄H₃₂O₇

[ 分子量 ]:
432.507

[ 闪点 ]:
302.6±30.1 °C

[ 精确质量 ]:
432.214813

[ PSA ]:
75.61000

[ LogP ]:
4.18

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
DMSO: ≥13mg/mL

五味子醇甲MSDS

详细MSDS(安全技术说明书)

五味子醇甲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP1626000

CHEMICAL NAME :: Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxy-, stereoisomer

CAS REGISTRY NUMBER :: 7432-28-2

LAST UPDATED :: 199106

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H32-O7

MOLECULAR WEIGHT :: 432.56

WISWESSER LINE NOTATION :: L B686&T&J CO1 DO1 EO1 IQ I1 J1 NO1 OO1 PO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1448 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 101,1030,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 518 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 101,1030,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1861 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 101,1030,1981

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五味子醇甲安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ 危险类别 ]:
9.0

[ 海关编码 ]:
2932999099

五味子醇甲上下游产品

五味子醇甲上游产品

五味子醇甲下游产品

五味子醇甲海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

五味子醇甲文献

Effects of acupuncture at ST36 on pharmacokinetics of Schisandra lignans in rats.

Acupunct. Med. 33 , 223-9, (2015)

To investigate the influence of acupuncture at ST36 on the pharmacokinetics of Schisandra lignans including schisandrin, deoxyschisandrin and schisandrin B after intragastric administration of Schisan...

Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.

J. Ethnopharmacol. 166 , 305-12, (2015)

Fuzheng Huayu recipe (FZHY) is formulated on the basis of Chinese medicine theory in treating liver fibrosis.To illuminate the influence of the pathological state of liver fibrosis on the pharmacokine...

The Lignan-containing Extract of Schisandra chinensis Berries Inhibits the Growth of Chlamydia pneumonia.

Nat. Prod. Commun. 10 , 1001-4, (2015)

The purpose of this study was to investigate the effect and selectivity of an extract of Schisandra chinensis berries against Chlamydia pneumoniae and C. trachomatis. Among the ethnopharmacological us...

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