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盐酸阿夫唑嗪

盐酸阿夫唑嗪用途

Alfuzosin盐酸盐是α1肾上腺素受体拮抗剂,可作用于良性前列腺增生(BPH)。

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盐酸阿夫唑嗪名称

[ CAS 号 ]:
81403-68-1

[ 中文名 ]:
盐酸阿夫唑嗪

[ 英文名 ]:
Alfuzosin hydrochloride

[中文别名 ]:

[英文别名 ]:

SL 77 499-10
Uroxatral
MFCD00879135
Alfuzosin HCl
SL 77-499-10
Alfuzosin hydrochloride
Alfuzosin (hydrochloride)

盐酸阿夫唑嗪生物活性

[ 描述 ]:

Alfuzosin盐酸盐是α1肾上腺素受体拮抗剂,可作用于良性前列腺增生(BPH)。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

天然产物 >> 生物碱

研究领域 >> 内分泌

[参考文献]

[1]. Wilde MI, et al. Alfuzosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in benign prostatic hyperplasia. Drugs. 1993 Mar;45(3):410-29.

[相关活性小分子]

盐酸阿夫唑嗪物理化学性质

[ 密度 ]:
1.272 g/cm3

[ 沸点 ]:
687.7ºC at 760 mmHg

[ 熔点 ]:
225°C

[ 分子式 ]:
C₁₉H₂₈ClN₅O₄

[ 分子量 ]:
425.910

[ 精确质量 ]:
425.182983

[ PSA ]:
111.83000

[ LogP ]:
3.12480

[ 外观性状 ]:
白色至灰白色固体

[ 储存条件 ]:
Store at RT

盐酸阿夫唑嗪MSDS

盐酸阿夫唑嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

盐酸阿夫唑嗪合成路线

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盐酸阿夫唑嗪制备

四氢呋喃羧酸和3-氨基丙腈反应,生成化合物(I).接着还原为化合物(Ⅱ),然后和4-氨基-2-氯-6,7-二甲氧基喹唑啉反应,得到的化合物(Ⅲ)再甲基化为阿夫唑嗪.

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盐酸阿夫唑嗪文献

Comparison ofcore–shelland totally porous ultra high performance liquid chromatographic stationary phases based on their selectivity towards alfuzosin compounds

J. Chromatogr. A. 1346 , 69-77, (2014)

• KUL procedure was adapted to testing of UHPLC stationary phases. • Classification of core–shell and UHPLC columns was performed. • Verification of the KUL results was based on the separation of alfu...

Temperature influencing permeation pattern of alfuzosin: an investigation using DoE.

Medicina (Kaunas.) 51 , 253-61, (2015)

There has been relatively little investigation of the effect of temperature on skin permeation compared to other methods of penetration enhancement. A principal physicochemical factor which controls t...

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